The Second International Symposium on the Molecular Biology of Breast Cancer

Ingvarsson, S. (Participant)

Faculty of Medicine

Activity: Participating in or organising an event › Organising a conference, workshop, ...

Period	12 Mar 2000 → 16 Mar 2000
Event type	Conference
Conference number	2
Location	Lillehammer, NorwayShow on map
Degree of Recognition	International

Documents & Links

IngvarssonMeetingRep2000
File: application/octet-stream, 6.96 MB
Type: Text

https://breast-cancer-research.biomedcentral.com/articles/supplements/volume-2-supplement-1
We have studied a set of 40 human lobular breast cancer for LOH at various chromosome locations, including intragenic FHIT markers at chromosome 3p14.2, and for mutations of the E-cadherin gene. A significantly lower level of LOH was detected at chromosome arms, 1p, 3p, 9p, 11q, 13q and 18q in lobular compared to ductal breast tumours. On the contrary, all lobular cases were found with LOH at chromosome 16q22.1, containing the E-cadherin locus. A significant association was detected between LOH at 3p and high S phase, LOH at 9p and low ER and PgR content, and between LOH at 17p and aneuploidy. LOH within the FHIT gene was detected in 16% of the lobular cases, which is significantly lower than detected in ductal breast cancer. A significant association was found between LOH at the FHIT gene and reduced Fhit expression detected by IHC. The expression of Fhit was reduced to a similar level in lobular and ductal breast cancer. Thus, genetic alterations within the FHIT gene leading to loss of Fhit proteins may play an important role in the carcinogenesis of a significant number of lobular breast cancers, even though the frequency of alterations is lower than in ductal breast cancer. Six novel mutations were detected within the E-cadherin gene in combination with LOH of the wild type E-cadherin locus and reduced E-cadherin expression. LOH at 13q was significantly associated with LOH at 7q, LOH at 11q and E-cadherin gene mutations. We conclude that there is a molecular difference in the pathogenesis of lobular and ductal breast cancer.
https://link.springer.com/content/pdf/10.1186/bcr122.pdf
The Second International Symposium on the Molecular Biology of Breast Cancer, held in Lillehammer, Norway, March 12-16, 2000, was organized by Anne-Lise Børresen-Dale (Symposium Chairman, Department of Genetics, The Norwegian Radium Hospital, University of Oslo, Norway, Per Eystein Lønning, Tone Ikdahl Andersen, Gry Aarum Geitvik, Ragnhild A. Lothe and Manuel R. Teixeira. Co-organizers of the meeting were: the American Association for Cancer Research, The European Association for Cancer Research and The Norwegian Cancer Society. The approximately 240 participants heard 36 formal lectures and 70 poster presentations and the symposium provided an optimal setting in which European and American breast cancer researchers could meet and exchange information. A great amount of progress has been made since the first symposium, 5 years ago. The focus was on new molecular findings in association with breast cancer progression and clinical implications were discussed. In this intense meeting many exciting new molecular approaches and findings in breast cancer were presented. Although much remains to be done it was obvious that a remarkable progress has been achieved and the field of molecular biology of cancer will continue to provide new information and understanding regarding the complex nature of neoplastic disease in the breast. Some of these findings will possibly lead to better diagnosis and treatment of breast cancer. Abstracts presented at the Lillehammer meeting have been published in Breast Cancer Research 2, 2000, and can be found at http://breast-cancer-research.com.
https://skemman.is/bitstream/1946/20428/1/IngvarssonOncolRep2000.pdf