A neuronal PI(3,4,5)P 3 -dependent program of oligodendrocyte precursor recruitment and myelination

Sandra Goebbels; Georg L. Wieser; Alexander Pieper; Sonia Spitzer; Bettina Weege; Kuo Yan; Julia M. Edgar; Oleksandr Yagensky; Sven P. Wichert; Amit Agarwal; Khalad Karram; Nicolas Renier; Marc Tessier-Lavigne; Moritz J. Rossner; Ragnhildur Thóra Káradóttir; Klaus Armin Nave

doi:10.1038/nn.4425

A neuronal PI(3,4,5)P 3 -dependent program of oligodendrocyte precursor recruitment and myelination

Sandra Goebbels
, Georg L. Wieser
, Alexander Pieper
, Sonia Spitzer
, Bettina Weege
, Kuo Yan
, Julia M. Edgar
, Oleksandr Yagensky
, Sven P. Wichert
, Amit Agarwal
, Khalad Karram
, Nicolas Renier
, Marc Tessier-Lavigne
, Moritz J. Rossner
, Ragnhildur Thóra Káradóttir
, Klaus Armin Nave

Faculty of Medicine

University of Iceland

Research output: Contribution to journal › Article › peer-review

Abstract

The molecular trigger of CNS myelination is unknown. By targeting Pten in cerebellar granule cells and activating the AKT1-mTOR pathway, we increased the caliber of normally unmyelinated axons and the expression of numerous genes encoding regulatory proteins. This led to the expansion of genetically wild-type oligodendrocyte progenitor cells, oligodendrocyte differentiation and de novo myelination of parallel fibers. Thus, a neuronal program dependent on the phosphoinositide PI(3,4,5)P 3 is sufficient to trigger all steps of myelination.

Original language	English
Pages (from-to)	10-15
Number of pages	6
Journal	Nature Neuroscience
Volume	20
Issue number	1
DOIs	https://doi.org/10.1038/nn.4425
Publication status	Published - 1 Jan 2017

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Goebbels, S., Wieser, G. L., Pieper, A., Spitzer, S., Weege, B., Yan, K., Edgar, J. M., Yagensky, O., Wichert, S. P., Agarwal, A., Karram, K., Renier, N., Tessier-Lavigne, M., Rossner, M. J., Káradóttir, R. T., & Nave, K. A. (2017). A neuronal PI(3,4,5)P 3 -dependent program of oligodendrocyte precursor recruitment and myelination. Nature Neuroscience, 20(1), 10-15. https://doi.org/10.1038/nn.4425

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title = "A neuronal PI(3,4,5)P 3 -dependent program of oligodendrocyte precursor recruitment and myelination",

abstract = "The molecular trigger of CNS myelination is unknown. By targeting Pten in cerebellar granule cells and activating the AKT1-mTOR pathway, we increased the caliber of normally unmyelinated axons and the expression of numerous genes encoding regulatory proteins. This led to the expansion of genetically wild-type oligodendrocyte progenitor cells, oligodendrocyte differentiation and de novo myelination of parallel fibers. Thus, a neuronal program dependent on the phosphoinositide PI(3,4,5)P 3 is sufficient to trigger all steps of myelination.",

author = "Sandra Goebbels and Wieser, \{Georg L.\} and Alexander Pieper and Sonia Spitzer and Bettina Weege and Kuo Yan and Edgar, \{Julia M.\} and Oleksandr Yagensky and Wichert, \{Sven P.\} and Amit Agarwal and Khalad Karram and Nicolas Renier and Marc Tessier-Lavigne and Rossner, \{Moritz J.\} and K{\'a}rad{\'o}ttir, \{Ragnhildur Th{\'o}ra\} and Nave, \{Klaus Armin\}",

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doi = "10.1038/nn.4425",

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Goebbels, S, Wieser, GL, Pieper, A, Spitzer, S, Weege, B, Yan, K, Edgar, JM, Yagensky, O, Wichert, SP, Agarwal, A, Karram, K, Renier, N, Tessier-Lavigne, M, Rossner, MJ, Káradóttir, RT & Nave, KA 2017, 'A neuronal PI(3,4,5)P 3 -dependent program of oligodendrocyte precursor recruitment and myelination', Nature Neuroscience, vol. 20, no. 1, pp. 10-15. https://doi.org/10.1038/nn.4425

TY - JOUR

T1 - A neuronal PI(3,4,5)P 3 -dependent program of oligodendrocyte precursor recruitment and myelination

AU - Goebbels, Sandra

AU - Wieser, Georg L.

AU - Pieper, Alexander

AU - Spitzer, Sonia

AU - Weege, Bettina

AU - Yan, Kuo

AU - Edgar, Julia M.

AU - Yagensky, Oleksandr

AU - Wichert, Sven P.

AU - Agarwal, Amit

AU - Karram, Khalad

AU - Renier, Nicolas

AU - Tessier-Lavigne, Marc

AU - Rossner, Moritz J.

AU - Káradóttir, Ragnhildur Thóra

AU - Nave, Klaus Armin

PY - 2017/1/1

Y1 - 2017/1/1

N2 - The molecular trigger of CNS myelination is unknown. By targeting Pten in cerebellar granule cells and activating the AKT1-mTOR pathway, we increased the caliber of normally unmyelinated axons and the expression of numerous genes encoding regulatory proteins. This led to the expansion of genetically wild-type oligodendrocyte progenitor cells, oligodendrocyte differentiation and de novo myelination of parallel fibers. Thus, a neuronal program dependent on the phosphoinositide PI(3,4,5)P 3 is sufficient to trigger all steps of myelination.

AB - The molecular trigger of CNS myelination is unknown. By targeting Pten in cerebellar granule cells and activating the AKT1-mTOR pathway, we increased the caliber of normally unmyelinated axons and the expression of numerous genes encoding regulatory proteins. This led to the expansion of genetically wild-type oligodendrocyte progenitor cells, oligodendrocyte differentiation and de novo myelination of parallel fibers. Thus, a neuronal program dependent on the phosphoinositide PI(3,4,5)P 3 is sufficient to trigger all steps of myelination.

UR - https://www.scopus.com/pages/publications/84992343449

U2 - 10.1038/nn.4425

DO - 10.1038/nn.4425

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SN - 1097-6256

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SP - 10

EP - 15

JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 1

ER -

A neuronal PI(3,4,5)P 3 -dependent program of oligodendrocyte precursor recruitment and myelination

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