TY - JOUR
T1 - Additive Effects of Moderate Dietary Salt Reduction and Captopril in Hypertension
AU - KRISTINSSON, ARNI
AU - HARDARSON, THORDUR
AU - PALSSON, KJARTAN
AU - PETURSSON, MAGNUS KARL
AU - SNORRASON, SNORRI P.
AU - THORGEIRSSON, GUDMUNDUR
PY - 1988
Y1 - 1988
N2 - ABSTRACT In a randomized, cross‐over study 27 patients had diastolic blood pressure of ≥ 96 mmHg during four visits without treatment. Following captopril 25 mg b.i.d. nine patients' blood pressure was ≤ 90 mmHg. The remaining 18 were randomized into two treatment modalities, captopril and moderate dietary salt reduction, and captopril and hydrochlorothiazide 25 mg daily. Following a wash‐out period the groups crossed over to the alternative treatment. At the end of the control period the average blood pressure was 151/100 ± 12/6 mmHg recumbent and 140/91 ± 11/7 standing, following captopril 144/94 ± 13/5 and 132/92 ± 12/6, respectively, with low salt diet addded to captopril 140/91 ± 12/6 and 128/89 ± 11/6 and with hydrochlorothiazide and captopril 133/86 ± 12/7 and 120/84 ± 11/7 mmHg supine and erect, respectively. It is concluded that moderate dietary salt reduction, which is easily advised, will significantly potentiate the blood pressure fall following captopril treatment in moderate arterial hypertension. 1988 Association for the Publication of the Journal of Internal Medicine
AB - ABSTRACT In a randomized, cross‐over study 27 patients had diastolic blood pressure of ≥ 96 mmHg during four visits without treatment. Following captopril 25 mg b.i.d. nine patients' blood pressure was ≤ 90 mmHg. The remaining 18 were randomized into two treatment modalities, captopril and moderate dietary salt reduction, and captopril and hydrochlorothiazide 25 mg daily. Following a wash‐out period the groups crossed over to the alternative treatment. At the end of the control period the average blood pressure was 151/100 ± 12/6 mmHg recumbent and 140/91 ± 11/7 standing, following captopril 144/94 ± 13/5 and 132/92 ± 12/6, respectively, with low salt diet addded to captopril 140/91 ± 12/6 and 128/89 ± 11/6 and with hydrochlorothiazide and captopril 133/86 ± 12/7 and 120/84 ± 11/7 mmHg supine and erect, respectively. It is concluded that moderate dietary salt reduction, which is easily advised, will significantly potentiate the blood pressure fall following captopril treatment in moderate arterial hypertension. 1988 Association for the Publication of the Journal of Internal Medicine
KW - captopril
KW - dietary salt reduction
KW - hypertension
UR - https://www.scopus.com/pages/publications/0023931436
U2 - 10.1111/j.0954-6820.1988.tb15777.x
DO - 10.1111/j.0954-6820.1988.tb15777.x
M3 - Article
C2 - 3279725
SN - 0001-6101
VL - 223
SP - 133
EP - 137
JO - Acta Medica Scandinavica
JF - Acta Medica Scandinavica
IS - 2
ER -