Amplification of c-myc and pvt-1 homologous sequences in acute nonlymphatic leukemia

Charlotte Asker; Cristina Mareni; Domenico Coviello; Sigurdur Ingvarsson; Mario Sessarego; Paola Origone; George Klein; Janos Sumeigi

doi:10.1016/0145-2126(88)90120-8

Amplification of c-myc and pvt-1 homologous sequences in acute nonlymphatic leukemia

Charlotte Asker
, Cristina Mareni
, Domenico Coviello
, Sigurdur Ingvarsson
, Mario Sessarego
, Paola Origone
, George Klein
, Janos Sumeigi

Faculty of Medicine

University of Iceland

Research output: Contribution to journal › Article › peer-review

Abstract

Leukemic cells with double minute (DM) chromosomes from an ANLL(M1) patient were found to carry 10-15 fold amplified c-myc sequences. The linked pvt-l-like locus was amplified at the same level, suggesting that the c-myc amplicon is at least 300 kb in size.

Original language	English
Pages (from-to)	523-527
Number of pages	5
Journal	Leukemia Research
Volume	12
Issue number	6
DOIs	https://doi.org/10.1016/0145-2126(88)90120-8
Publication status	Published - 1988

Other keywords

amplification
c-myc
leukemia

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10.1016/0145-2126(88)90120-8

Cite this

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title = "Amplification of c-myc and pvt-1 homologous sequences in acute nonlymphatic leukemia",

abstract = "Leukemic cells with double minute (DM) chromosomes from an ANLL(M1) patient were found to carry 10-15 fold amplified c-myc sequences. The linked pvt-l-like locus was amplified at the same level, suggesting that the c-myc amplicon is at least 300 kb in size.",

keywords = "amplification, c-myc, leukemia",

author = "Charlotte Asker and Cristina Mareni and Domenico Coviello and Sigurdur Ingvarsson and Mario Sessarego and Paola Origone and George Klein and Janos Sumeigi",

note = "Funding Information: Acknowledgements--The authors wish to thank Drs R. C. Gallo, G. Vande Woude and P. Jolicoeur for DNA probes. This work was supported by CNR grant No. 85.00537.04, Finalizzato Oncologia No. 86.00284.44, and PHS grant number 3R01CA14054 awarded by the National Cancer Institute, Department of Health and Human Services, the Swedish Cancer Society and the Balthzar von Platen Foundation. J.S. was recipient of a fellowship from CRI/Concern, C.A. was recipient of a fellowship from the Swedish Cancer Society.",

year = "1988",

doi = "10.1016/0145-2126(88)90120-8",

language = "English",

volume = "12",

pages = "523--527",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Ltd.",

number = "6",

}

TY - JOUR

T1 - Amplification of c-myc and pvt-1 homologous sequences in acute nonlymphatic leukemia

AU - Asker, Charlotte

AU - Mareni, Cristina

AU - Coviello, Domenico

AU - Ingvarsson, Sigurdur

AU - Sessarego, Mario

AU - Origone, Paola

AU - Klein, George

AU - Sumeigi, Janos

N1 - Funding Information: Acknowledgements--The authors wish to thank Drs R. C. Gallo, G. Vande Woude and P. Jolicoeur for DNA probes. This work was supported by CNR grant No. 85.00537.04, Finalizzato Oncologia No. 86.00284.44, and PHS grant number 3R01CA14054 awarded by the National Cancer Institute, Department of Health and Human Services, the Swedish Cancer Society and the Balthzar von Platen Foundation. J.S. was recipient of a fellowship from CRI/Concern, C.A. was recipient of a fellowship from the Swedish Cancer Society.

PY - 1988

Y1 - 1988

N2 - Leukemic cells with double minute (DM) chromosomes from an ANLL(M1) patient were found to carry 10-15 fold amplified c-myc sequences. The linked pvt-l-like locus was amplified at the same level, suggesting that the c-myc amplicon is at least 300 kb in size.

AB - Leukemic cells with double minute (DM) chromosomes from an ANLL(M1) patient were found to carry 10-15 fold amplified c-myc sequences. The linked pvt-l-like locus was amplified at the same level, suggesting that the c-myc amplicon is at least 300 kb in size.

KW - amplification

KW - c-myc

KW - leukemia

UR - https://www.scopus.com/pages/publications/0023790354

U2 - 10.1016/0145-2126(88)90120-8

DO - 10.1016/0145-2126(88)90120-8

M3 - Article

C2 - 3405005

SN - 0145-2126

VL - 12

SP - 523

EP - 527

JO - Leukemia Research

JF - Leukemia Research

IS - 6

ER -

Amplification of c-myc and pvt-1 homologous sequences in acute nonlymphatic leukemia

Abstract

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