Abstract
This study examined anxiety in Wiedemann–Steiner syndrome (WSS). Eighteen caregivers and participants with WSS completed the parent- and self-report versions of the Screen for Child Anxiety Related Disorder or the adapted version of the Screen for Adult Anxiety Related Disorder. Approximately 33.33% of parents and 65% of participants with WSS rated in the clinical range for overall anxiety. Across anxiety subtypes, parents primarily indicated concerns with Separation Anxiety (72%), which was also endorsed by the majority of participants with WSS (82%). The emergent trend showed Total Anxiety increased with age based on parent-informant ratings. The behavioral phenotype of WSS includes elevated anxiety. Clinical management should include incorporating early behavioral interventions to bolster emotion regulation given the observed risk of anxiety with age.
| Original language | English |
|---|---|
| Pages (from-to) | 437-444 |
| Number of pages | 8 |
| Journal | American Journal of Medical Genetics, Part A |
| Volume | 191 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2023 |
Bibliographical note
Funding Information: R.N. and H.T.B. are supported by grants from the WSS Foundation, J.A.F. has support from The Hartwell Foundation (Individual Biomedical Research Award) and the NIH (K08HD086250), and J.H. has support from the National Institute of Child Health and Development (K23HD101646). This study was also supported by Kennedy Krieger IDDRC NIH (P50HD103538). Funding Information: We would like to thank the patients and their families who participated in this study, as well as acknowledging the support of the Wiedemann–Steiner Syndrome Foundation. Publisher Copyright: © 2022 Wiley Periodicals LLC. © 2022 Wiley Periodicals LLC.Other keywords
- Abnormalities, Multiple/genetics
- Anxiety
- Humans
- Intellectual Disability/genetics
- KMT2A
- anxiety
- developmental psychopathology
- genetics/genetic disorders
- mental health