TY - JOUR
T1 - Barriers to and Enablers of Supporting Deprescribing Benzodiazepines in Older Adults
T2 - A Survey of European Nonphysician Healthcare Professionals
AU - Shapoval, Vladyslav
AU - Evrard, Perrine
AU - Sibille, François Xavier
AU - López-Toribio, María
AU - Dalleur, Olivia
AU - Aubert, Carole E
AU - Bolt, Lucy
AU - Tsoutsi, Vagioula
AU - Ntafouli, Maria
AU - Maldonado, Laura Fernández
AU - Miralles, Ramon
AU - Wichniak, Adam
AU - Gustavsson, Katarzyna
AU - Wyller, Torgeir Bruun
AU - Callegari, Enrico
AU - Grimshaw, Jeremy M
AU - Presseau, Justin
AU - Henrard, Séverine
AU - Spinewine, Anne
N1 - Publisher Copyright: © 2025 The Author(s). Basic & Clinical Pharmacology & Toxicology published by John Wiley & Sons Ltd on behalf of Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).
PY - 2025/10
Y1 - 2025/10
N2 - Although physicians are primarily responsible for Benzodiazepine Receptor Agonist (BZRA) deprescribing, nonphysician healthcare professionals (HCPs) can support deprescribing. This study explored barriers to and enablers of BZRA deprescribing among nonphysician HCPs. We surveyed 258 HCPs (63.2% nurses) working in hospital settings across six European countries using a questionnaire based on the Theoretical Domain Framework (TDF). Logistic regression assessed associations between TDF domains and both intentions to support and routine engagement in BZRA deprescribing. Major barriers (TDF items with mean < 3) were found in the goals (competing priorities), environmental context and resources (time and staff lack) and social influences (patient reluctance) domains. Five TDF domains were associated with a stronger intention to support deprescribing: social/professional role and identity (OR, 3.08; 95% CI, 1.77–5.46); beliefs about consequences (OR, 1.91; 95% CI, 1.07–3.34); memory, attention and decision processing (OR, 1.80; 95% CI, 1.16–2.82); intention to promote alternatives (OR, 1.63; 95% CI, 1.07–2.49); and reinforcement (OR, 1.57; 95% CI, 1.08–2.29). Knowledge was the only domain associated with routine BZRA deprescribing support (OR, 1.16; 95% CI, 1.06–1.27). Different categories of HCPs face similar major barriers, but barriers vary across HCP categories and countries. Context-specific, targeted interventions may enhance support for BZRA deprescribing.
AB - Although physicians are primarily responsible for Benzodiazepine Receptor Agonist (BZRA) deprescribing, nonphysician healthcare professionals (HCPs) can support deprescribing. This study explored barriers to and enablers of BZRA deprescribing among nonphysician HCPs. We surveyed 258 HCPs (63.2% nurses) working in hospital settings across six European countries using a questionnaire based on the Theoretical Domain Framework (TDF). Logistic regression assessed associations between TDF domains and both intentions to support and routine engagement in BZRA deprescribing. Major barriers (TDF items with mean < 3) were found in the goals (competing priorities), environmental context and resources (time and staff lack) and social influences (patient reluctance) domains. Five TDF domains were associated with a stronger intention to support deprescribing: social/professional role and identity (OR, 3.08; 95% CI, 1.77–5.46); beliefs about consequences (OR, 1.91; 95% CI, 1.07–3.34); memory, attention and decision processing (OR, 1.80; 95% CI, 1.16–2.82); intention to promote alternatives (OR, 1.63; 95% CI, 1.07–2.49); and reinforcement (OR, 1.57; 95% CI, 1.08–2.29). Knowledge was the only domain associated with routine BZRA deprescribing support (OR, 1.16; 95% CI, 1.06–1.27). Different categories of HCPs face similar major barriers, but barriers vary across HCP categories and countries. Context-specific, targeted interventions may enhance support for BZRA deprescribing.
KW - Adult
KW - Aged
KW - Attitude of Health Personnel
KW - Benzodiazepines/adverse effects
KW - Deprescriptions
KW - Europe
KW - Female
KW - GABA-A Receptor Agonists/administration & dosage
KW - Health Personnel/psychology
KW - Humans
KW - Male
KW - Middle Aged
KW - Surveys and Questionnaires
KW - benzodiazepines
KW - deprescribing
KW - medication safety
KW - nonphysician staff
KW - older adults
UR - https://www.scopus.com/pages/publications/105014801128
U2 - 10.1111/bcpt.70100
DO - 10.1111/bcpt.70100
M3 - Article
C2 - 40898700
SN - 1742-7835
VL - 137
JO - Basic and clinical pharmacology and toxicology
JF - Basic and clinical pharmacology and toxicology
IS - 4
M1 - e70100
ER -