Comparison of bovine milk oligosaccharides in native North European cattle breeds

Anne Vuholm Sunds; Apichaya Bunyatratchata; Randall Robinson; Maria Glantz; Marie Paulsson; Daiva Leskauskaite; Anne Pihlanto; Ragnhild Inglingstad; Tove G. Devold; Gerd E. Vegarud; Bryndís Eva Birgisdóttir; María Guðjónsdóttir; Daniela Barile; Lotte Bach Larsen; Nina Aagaard Poulsen

doi:10.1016/j.idairyj.2020.104917

Comparison of bovine milk oligosaccharides in native North European cattle breeds

Anne Vuholm Sunds
, Apichaya Bunyatratchata
, Randall Robinson
, Maria Glantz
, Marie Paulsson
, Daiva Leskauskaite
, Anne Pihlanto
, Ragnhild Inglingstad
, Tove G. Devold
, Gerd E. Vegarud
, Bryndís Eva Birgisdóttir
, María Guðjónsdóttir
, Daniela Barile
, Lotte Bach Larsen
, Nina Aagaard Poulsen

Faculty of Food Science and Nutrition

University of Iceland

Research output: Contribution to journal › Article › peer-review

Abstract

Milk oligosaccharides are of high interest due to their bioactive properties. This study is the first to characterise milk oligosaccharides from native North European cattle breeds, as represented by 80 milk samples collected from eight native breeds originated from Norway (Norwegian Doela cattle and Norwegian Telemark cattle), Sweden (Swedish Mountain cattle), Denmark (Danish Red anno 1970), Iceland (Icelandic cattle), Lithuania (native Lithuanian Black and White) and Finland (Western Finncattle and Eastern Finncattle). Using high-performance liquid-chromatography chip/quadrupole time-of-flight mass-spectrometry, 18 unique monosaccharide compositions and a multitude of isomers were identified. No N-glycolylneuraminic acid was identified among these breeds. Western Finncattle milk was most abundant in neutral, acidic and fucosylated oligosaccharides. Further, Eastern Finncattle milk was significantly higher in acidic oligosaccharides and Icelandic cattle milk significantly higher in fucosylated oligosaccharides, compared to the mean. This study highlights specific native breeds of particular interest for future exploitation of milk oligosaccharides and breeding strategies.

Original language	English
Article number	104917
Journal	International Dairy Journal
Volume	114
DOIs	https://doi.org/10.1016/j.idairyj.2020.104917
Publication status	Published - Mar 2021

Bibliographical note

Funding text The authors thank the farmers and co-workers in the different countries providing the milk samples. Further, the authors are grateful for the financial support from Aarhus University Research Foundation (AUFF, Aarhus, Denmark), Frands Christian Frantsen Fund (Aarhus, Denmark), as well as the Graduate School of Science and Technology (GSST) at Aarhus University (Aarhus, Denmark). The UC Davis authors acknowledge partial support from the National Institutes of Health , grant R01AT008759 . Publisher Copyright: © 2020 Elsevier Ltd

Other keywords

Comparison
Milk
Northern Europe
Oligosaccharides

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10.1016/j.idairyj.2020.104917

Cite this

Sunds, A. V., Bunyatratchata, A., Robinson, R., Glantz, M., Paulsson, M., Leskauskaite, D., Pihlanto, A., Inglingstad, R., Devold, T. G., Vegarud, G. E., Birgisdóttir, B. E., Guðjónsdóttir, M., Barile, D., Larsen, L. B., & Poulsen, N. A. (2021). Comparison of bovine milk oligosaccharides in native North European cattle breeds. International Dairy Journal, 114, Article 104917. https://doi.org/10.1016/j.idairyj.2020.104917

@article{b0e41ebeb0724b5389a28ae5a14e2cb9,

title = "Comparison of bovine milk oligosaccharides in native North European cattle breeds",

abstract = "Milk oligosaccharides are of high interest due to their bioactive properties. This study is the first to characterise milk oligosaccharides from native North European cattle breeds, as represented by 80 milk samples collected from eight native breeds originated from Norway (Norwegian Doela cattle and Norwegian Telemark cattle), Sweden (Swedish Mountain cattle), Denmark (Danish Red anno 1970), Iceland (Icelandic cattle), Lithuania (native Lithuanian Black and White) and Finland (Western Finncattle and Eastern Finncattle). Using high-performance liquid-chromatography chip/quadrupole time-of-flight mass-spectrometry, 18 unique monosaccharide compositions and a multitude of isomers were identified. No N-glycolylneuraminic acid was identified among these breeds. Western Finncattle milk was most abundant in neutral, acidic and fucosylated oligosaccharides. Further, Eastern Finncattle milk was significantly higher in acidic oligosaccharides and Icelandic cattle milk significantly higher in fucosylated oligosaccharides, compared to the mean. This study highlights specific native breeds of particular interest for future exploitation of milk oligosaccharides and breeding strategies.",

keywords = "Comparison, Milk, Northern Europe, Oligosaccharides",

author = "Sunds, \{Anne Vuholm\} and Apichaya Bunyatratchata and Randall Robinson and Maria Glantz and Marie Paulsson and Daiva Leskauskaite and Anne Pihlanto and Ragnhild Inglingstad and Devold, \{Tove G.\} and Vegarud, \{Gerd E.\} and Birgisd{\'o}ttir, \{Brynd{\'i}s Eva\} and Mar{\'i}a Gu{\dh}j{\'o}nsd{\'o}ttir and Daniela Barile and Larsen, \{Lotte Bach\} and Poulsen, \{Nina Aagaard\}",

note = "Funding text The authors thank the farmers and co-workers in the different countries providing the milk samples. Further, the authors are grateful for the financial support from Aarhus University Research Foundation (AUFF, Aarhus, Denmark), Frands Christian Frantsen Fund (Aarhus, Denmark), as well as the Graduate School of Science and Technology (GSST) at Aarhus University (Aarhus, Denmark). The UC Davis authors acknowledge partial support from the National Institutes of Health , grant R01AT008759 . Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2021",

month = mar,

doi = "10.1016/j.idairyj.2020.104917",

language = "English",

volume = "114",

journal = "International Dairy Journal",

issn = "0958-6946",

publisher = "Elsevier B.V.",

}

Sunds, AV, Bunyatratchata, A, Robinson, R, Glantz, M, Paulsson, M, Leskauskaite, D, Pihlanto, A, Inglingstad, R, Devold, TG, Vegarud, GE, Birgisdóttir, BE , Guðjónsdóttir, M, Barile, D, Larsen, LB & Poulsen, NA 2021, 'Comparison of bovine milk oligosaccharides in native North European cattle breeds', International Dairy Journal, vol. 114, 104917. https://doi.org/10.1016/j.idairyj.2020.104917

TY - JOUR

T1 - Comparison of bovine milk oligosaccharides in native North European cattle breeds

AU - Sunds, Anne Vuholm

AU - Bunyatratchata, Apichaya

AU - Robinson, Randall

AU - Glantz, Maria

AU - Paulsson, Marie

AU - Leskauskaite, Daiva

AU - Pihlanto, Anne

AU - Inglingstad, Ragnhild

AU - Devold, Tove G.

AU - Vegarud, Gerd E.

AU - Birgisdóttir, Bryndís Eva

AU - Guðjónsdóttir, María

AU - Barile, Daniela

AU - Larsen, Lotte Bach

AU - Poulsen, Nina Aagaard

N1 - Funding text The authors thank the farmers and co-workers in the different countries providing the milk samples. Further, the authors are grateful for the financial support from Aarhus University Research Foundation (AUFF, Aarhus, Denmark), Frands Christian Frantsen Fund (Aarhus, Denmark), as well as the Graduate School of Science and Technology (GSST) at Aarhus University (Aarhus, Denmark). The UC Davis authors acknowledge partial support from the National Institutes of Health , grant R01AT008759 . Publisher Copyright: © 2020 Elsevier Ltd

PY - 2021/3

Y1 - 2021/3

N2 - Milk oligosaccharides are of high interest due to their bioactive properties. This study is the first to characterise milk oligosaccharides from native North European cattle breeds, as represented by 80 milk samples collected from eight native breeds originated from Norway (Norwegian Doela cattle and Norwegian Telemark cattle), Sweden (Swedish Mountain cattle), Denmark (Danish Red anno 1970), Iceland (Icelandic cattle), Lithuania (native Lithuanian Black and White) and Finland (Western Finncattle and Eastern Finncattle). Using high-performance liquid-chromatography chip/quadrupole time-of-flight mass-spectrometry, 18 unique monosaccharide compositions and a multitude of isomers were identified. No N-glycolylneuraminic acid was identified among these breeds. Western Finncattle milk was most abundant in neutral, acidic and fucosylated oligosaccharides. Further, Eastern Finncattle milk was significantly higher in acidic oligosaccharides and Icelandic cattle milk significantly higher in fucosylated oligosaccharides, compared to the mean. This study highlights specific native breeds of particular interest for future exploitation of milk oligosaccharides and breeding strategies.

AB - Milk oligosaccharides are of high interest due to their bioactive properties. This study is the first to characterise milk oligosaccharides from native North European cattle breeds, as represented by 80 milk samples collected from eight native breeds originated from Norway (Norwegian Doela cattle and Norwegian Telemark cattle), Sweden (Swedish Mountain cattle), Denmark (Danish Red anno 1970), Iceland (Icelandic cattle), Lithuania (native Lithuanian Black and White) and Finland (Western Finncattle and Eastern Finncattle). Using high-performance liquid-chromatography chip/quadrupole time-of-flight mass-spectrometry, 18 unique monosaccharide compositions and a multitude of isomers were identified. No N-glycolylneuraminic acid was identified among these breeds. Western Finncattle milk was most abundant in neutral, acidic and fucosylated oligosaccharides. Further, Eastern Finncattle milk was significantly higher in acidic oligosaccharides and Icelandic cattle milk significantly higher in fucosylated oligosaccharides, compared to the mean. This study highlights specific native breeds of particular interest for future exploitation of milk oligosaccharides and breeding strategies.

KW - Comparison

KW - Milk

KW - Northern Europe

KW - Oligosaccharides

UR - https://www.scopus.com/pages/publications/85097254559

U2 - 10.1016/j.idairyj.2020.104917

DO - 10.1016/j.idairyj.2020.104917

M3 - Article

SN - 0958-6946

VL - 114

JO - International Dairy Journal

JF - International Dairy Journal

M1 - 104917

ER -

Comparison of bovine milk oligosaccharides in native North European cattle breeds

Abstract

Bibliographical note

Other keywords

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