Depressive symptom profiles predict dementia onset and brain pathology in older persons. The AGES-Reykjavik study

Lotte Gerritsen; Sigurdur Sigurdsson; Pálmi V Jónsson; Vilmundur G Guðnason; Lenore J. Launer; Mirjam I. Geerlings

doi:10.1016/j.neurobiolaging.2021.09.025

Depressive symptom profiles predict dementia onset and brain pathology in older persons. The AGES-Reykjavik study

Lotte Gerritsen
, Sigurdur Sigurdsson
, Pálmi V Jónsson
, Vilmundur G Guðnason
, Lenore J. Launer
, Mirjam I. Geerlings

Landspitali, University of Iceland

Research output: Contribution to journal › Article › peer-review

Abstract

Late-life depression (LLD) increases risk for dementia and brain pathology, but possibly this is only true for one or more symptom profiles of LLD. In 4354 participants (76 ± 5 years; 58% female) from the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study, we identified five LLD symptom profiles, based on the Geriatric Depression Scale-15 (no LLD (57%); apathy (31%); apathy with emptiness (2%), mild LLD (8%) and severe LLD (2%)). Cox regression analyses showed that severe LLD, mild LLD and apathy increased risk of dementia up to 12 years, compared to no LLD. Additionally, hippocampal volume loss and white matter lesion increase, were assessed on 1.5 T MR images, at baseline and after 5 years follow-up. Only severe LLD showed increased WML volume over time, but not on hippocampal volume loss. WML increase over time mediated partially the relation between mild LLD and dementia but not for the other symptom profiles. It appears that hippocampal atrophy and LLD are independent predictors for dementia incidence, whereas for mild LLD the risk for dementia is partially mediated by WML changes.

Original language	English
Pages (from-to)	14-23
Number of pages	10
Journal	Neurobiology of Aging
Volume	111
DOIs	https://doi.org/10.1016/j.neurobiolaging.2021.09.025
Publication status	Published - 1 Mar 2022

Bibliographical note

Funding Information: The AGES Reykjavik study was funded by the Icelandic Heart Association, National Institute of Aging contracts ( N01-AG-12100 and HHSN271201200022C ) and Althingi the Icelandic Parliament. This work was supported by Alzheimer Nederland (grant number WE.03-2017-06 ) Publisher Copyright: © 2021 Copyright © 2021. Published by Elsevier Inc.

Other keywords

Aged
Aged, 80 and over
Aging/pathology
Alzheimer's disease
Apathy
Dementia/etiology
Depression/complications
Female
Forecasting
Gene-Environment Interaction
Hippocampus/pathology
Humans
Male
Organ Size
Patient Acuity
White Matter/pathology
dementia
hippocampus
late-life depression
white matter lesions

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10.1016/j.neurobiolaging.2021.09.025

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@article{9ad63aa9040944729b1f6299b5a321c4,

title = "Depressive symptom profiles predict dementia onset and brain pathology in older persons. The AGES-Reykjavik study",

abstract = "Late-life depression (LLD) increases risk for dementia and brain pathology, but possibly this is only true for one or more symptom profiles of LLD. In 4354 participants (76 ± 5 years; 58\% female) from the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study, we identified five LLD symptom profiles, based on the Geriatric Depression Scale-15 (no LLD (57\%); apathy (31\%); apathy with emptiness (2\%), mild LLD (8\%) and severe LLD (2\%)). Cox regression analyses showed that severe LLD, mild LLD and apathy increased risk of dementia up to 12 years, compared to no LLD. Additionally, hippocampal volume loss and white matter lesion increase, were assessed on 1.5 T MR images, at baseline and after 5 years follow-up. Only severe LLD showed increased WML volume over time, but not on hippocampal volume loss. WML increase over time mediated partially the relation between mild LLD and dementia but not for the other symptom profiles. It appears that hippocampal atrophy and LLD are independent predictors for dementia incidence, whereas for mild LLD the risk for dementia is partially mediated by WML changes.",

keywords = "Aged, Aged, 80 and over, Aging/pathology, Alzheimer's disease, Apathy, Dementia/etiology, Depression/complications, Female, Forecasting, Gene-Environment Interaction, Hippocampus/pathology, Humans, Male, Organ Size, Patient Acuity, White Matter/pathology, dementia, hippocampus, late-life depression, white matter lesions",

author = "Lotte Gerritsen and Sigurdur Sigurdsson and J{\'o}nsson, \{P{\'a}lmi V\} and Gu{\dh}nason, \{Vilmundur G\} and Launer, \{Lenore J.\} and Geerlings, \{Mirjam I.\}",

note = "Funding Information: The AGES Reykjavik study was funded by the Icelandic Heart Association, National Institute of Aging contracts ( N01-AG-12100 and HHSN271201200022C ) and Althingi the Icelandic Parliament. This work was supported by Alzheimer Nederland (grant number WE.03-2017-06 ) Publisher Copyright: {\textcopyright} 2021 Copyright {\textcopyright} 2021. Published by Elsevier Inc.",

year = "2022",

month = mar,

day = "1",

doi = "10.1016/j.neurobiolaging.2021.09.025",

language = "English",

volume = "111",

pages = "14--23",

journal = "Neurobiology of Aging",

issn = "0197-4580",

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T1 - Depressive symptom profiles predict dementia onset and brain pathology in older persons. The AGES-Reykjavik study

AU - Gerritsen, Lotte

AU - Sigurdsson, Sigurdur

AU - Jónsson, Pálmi V

AU - Guðnason, Vilmundur G

AU - Launer, Lenore J.

AU - Geerlings, Mirjam I.

N1 - Funding Information: The AGES Reykjavik study was funded by the Icelandic Heart Association, National Institute of Aging contracts ( N01-AG-12100 and HHSN271201200022C ) and Althingi the Icelandic Parliament. This work was supported by Alzheimer Nederland (grant number WE.03-2017-06 ) Publisher Copyright: © 2021 Copyright © 2021. Published by Elsevier Inc.

PY - 2022/3/1

Y1 - 2022/3/1

N2 - Late-life depression (LLD) increases risk for dementia and brain pathology, but possibly this is only true for one or more symptom profiles of LLD. In 4354 participants (76 ± 5 years; 58% female) from the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study, we identified five LLD symptom profiles, based on the Geriatric Depression Scale-15 (no LLD (57%); apathy (31%); apathy with emptiness (2%), mild LLD (8%) and severe LLD (2%)). Cox regression analyses showed that severe LLD, mild LLD and apathy increased risk of dementia up to 12 years, compared to no LLD. Additionally, hippocampal volume loss and white matter lesion increase, were assessed on 1.5 T MR images, at baseline and after 5 years follow-up. Only severe LLD showed increased WML volume over time, but not on hippocampal volume loss. WML increase over time mediated partially the relation between mild LLD and dementia but not for the other symptom profiles. It appears that hippocampal atrophy and LLD are independent predictors for dementia incidence, whereas for mild LLD the risk for dementia is partially mediated by WML changes.

AB - Late-life depression (LLD) increases risk for dementia and brain pathology, but possibly this is only true for one or more symptom profiles of LLD. In 4354 participants (76 ± 5 years; 58% female) from the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study, we identified five LLD symptom profiles, based on the Geriatric Depression Scale-15 (no LLD (57%); apathy (31%); apathy with emptiness (2%), mild LLD (8%) and severe LLD (2%)). Cox regression analyses showed that severe LLD, mild LLD and apathy increased risk of dementia up to 12 years, compared to no LLD. Additionally, hippocampal volume loss and white matter lesion increase, were assessed on 1.5 T MR images, at baseline and after 5 years follow-up. Only severe LLD showed increased WML volume over time, but not on hippocampal volume loss. WML increase over time mediated partially the relation between mild LLD and dementia but not for the other symptom profiles. It appears that hippocampal atrophy and LLD are independent predictors for dementia incidence, whereas for mild LLD the risk for dementia is partially mediated by WML changes.

KW - Aged

KW - Aged, 80 and over

KW - Aging/pathology

KW - Alzheimer's disease

KW - Apathy

KW - Dementia/etiology

KW - Depression/complications

KW - Female

KW - Forecasting

KW - Gene-Environment Interaction

KW - Hippocampus/pathology

KW - Humans

KW - Male

KW - Organ Size

KW - Patient Acuity

KW - White Matter/pathology

KW - dementia

KW - hippocampus

KW - late-life depression

KW - white matter lesions

UR - https://www.scopus.com/pages/publications/85121255018

U2 - 10.1016/j.neurobiolaging.2021.09.025

DO - 10.1016/j.neurobiolaging.2021.09.025

M3 - Article

C2 - 34923217

SN - 0197-4580

VL - 111

SP - 14

EP - 23

JO - Neurobiology of Aging

JF - Neurobiology of Aging

ER -

Depressive symptom profiles predict dementia onset and brain pathology in older persons. The AGES-Reykjavik study

Abstract

Bibliographical note

Other keywords

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