Drug-induced liver injury - Types and phenotypes

Drug-induced liver injury is an uncommon but challenging clinical problem with respect to both diagnosis and management.^1-3 Its incidence is estimated to be 14 to 19 cases per 100,000 persons, with jaundice accompanying 30% of cases.^4,5 Drug-induced liver injury is responsible for 3 to 5% of hospital admissions for jaundice⁶ and is the most frequent cause of acute liver failure in most Western countries, accounting for more than half of cases.^7,8 Advances have been made in our understanding of viral, autoimmune, and genetic liver diseases, as well as approaches to their prevention and treatment, but progress on these fronts has been modest in the case of drug-induced liver injury.