Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

Jari Lahti; Samuli Tuominen; Qiong Yang; Giulio Pergola; Shahzad Ahmad; Najaf Amin; Nicola J. Armstrong; Alexa Beiser; Katharina Bey; Joshua C. Bis; Eric Boerwinkle; Jan Bressler; Archie Campbell; Harry Campbell; Qiang Chen; Janie Corley; Simon R. Cox; Gail Davies; Philip L. De Jager; Eske M. Derks; Jessica D. Faul; Annette L. Fitzpatrick; Alison E. Fohner; Ian Ford; Myriam Fornage; Zachary Gerring; Hans J. Grabe; Francine Grodstein; Vilmundur Gudnason; Eleanor Simonsick; Elizabeth G. Holliday; Peter K. Joshi; Eero Kajantie; Jaakko Kaprio; Pauliina Karell; Luca Kleineidam; Maria J. Knol; Nicole A. Kochan; John B. Kwok; Markus Leber; Max Lam; Teresa Lee; Shuo Li; Anu Loukola; Tobias Luck; Riccardo E. Marioni; Karen A. Mather; Sarah Medland; Saira S. Mirza; Mike A. Nalls

doi:10.1038/s41380-022-01710-8

Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

Jari Lahti
, Samuli Tuominen
, Qiong Yang
, Giulio Pergola
, Shahzad Ahmad
, Najaf Amin
, Nicola J. Armstrong
, Alexa Beiser
, Katharina Bey
, Joshua C. Bis
, Eric Boerwinkle
, Jan Bressler
, Archie Campbell
, Harry Campbell
, Qiang Chen
, Janie Corley
, Simon R. Cox
, Gail Davies
, Philip L. De Jager
, Eske M. Derks

Jessica D. Faul, Annette L. Fitzpatrick, Alison E. Fohner, Ian Ford, Myriam Fornage, Zachary Gerring, Hans J. Grabe, Francine Grodstein, Vilmundur Gudnason, Eleanor Simonsick, Elizabeth G. Holliday, Peter K. Joshi, Eero Kajantie, Jaakko Kaprio, Pauliina Karell, Luca Kleineidam, Maria J. Knol, Nicole A. Kochan, John B. Kwok, Markus Leber, Max Lam, Teresa Lee, Shuo Li, Anu Loukola, Tobias Luck, Riccardo E. Marioni, Karen A. Mather, Sarah Medland, Saira S. Mirza, Mike A. Nalls

Faculty of Medicine

University of Iceland

Research output: Contribution to journal › Article › peer-review

Abstract

Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes.

Original language	English
Pages (from-to)	4419-4431
Number of pages	13
Journal	Molecular Psychiatry
Volume	27
Issue number	11
DOIs	https://doi.org/10.1038/s41380-022-01710-8
Publication status	Published - 16 Aug 2022

Bibliographical note

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Other keywords

Brain
Learning
Memory, Short-Term/physiology
Multifactorial Inheritance
Verbal Learning

Access to Document

10.1038/s41380-022-01710-8

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Cite this

Lahti, J., Tuominen, S., Yang, Q., Pergola, G., Ahmad, S., Amin, N., Armstrong, N. J., Beiser, A., Bey, K., Bis, J. C., Boerwinkle, E., Bressler, J., Campbell, A., Campbell, H., Chen, Q., Corley, J., Cox, S. R., Davies, G., De Jager, P. L., ... Nalls, M. A. (2022). Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning. Molecular Psychiatry, 27(11), 4419-4431. https://doi.org/10.1038/s41380-022-01710-8

@article{68215adb65d342d49aa0984e3dd6665a,

title = "Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning",

abstract = "Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes.",

keywords = "Brain, Learning, Memory, Short-Term/physiology, Multifactorial Inheritance, Verbal Learning",

author = "Jari Lahti and Samuli Tuominen and Qiong Yang and Giulio Pergola and Shahzad Ahmad and Najaf Amin and Armstrong, \{Nicola J.\} and Alexa Beiser and Katharina Bey and Bis, \{Joshua C.\} and Eric Boerwinkle and Jan Bressler and Archie Campbell and Harry Campbell and Qiang Chen and Janie Corley and Cox, \{Simon R.\} and Gail Davies and \{De Jager\}, \{Philip L.\} and Derks, \{Eske M.\} and Faul, \{Jessica D.\} and Fitzpatrick, \{Annette L.\} and Fohner, \{Alison E.\} and Ian Ford and Myriam Fornage and Zachary Gerring and Grabe, \{Hans J.\} and Francine Grodstein and Vilmundur Gudnason and Eleanor Simonsick and Holliday, \{Elizabeth G.\} and Joshi, \{Peter K.\} and Eero Kajantie and Jaakko Kaprio and Pauliina Karell and Luca Kleineidam and Knol, \{Maria J.\} and Kochan, \{Nicole A.\} and Kwok, \{John B.\} and Markus Leber and Max Lam and Teresa Lee and Shuo Li and Anu Loukola and Tobias Luck and Marioni, \{Riccardo E.\} and Mather, \{Karen A.\} and Sarah Medland and Mirza, \{Saira S.\} and Nalls, \{Mike A.\}",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = aug,

day = "16",

doi = "10.1038/s41380-022-01710-8",

language = "English",

volume = "27",

pages = "4419--4431",

journal = "Molecular Psychiatry",

issn = "1359-4184",

publisher = "Springer Nature",

number = "11",

}

Lahti, J, Tuominen, S, Yang, Q, Pergola, G, Ahmad, S, Amin, N, Armstrong, NJ, Beiser, A, Bey, K, Bis, JC, Boerwinkle, E, Bressler, J, Campbell, A, Campbell, H, Chen, Q, Corley, J, Cox, SR, Davies, G, De Jager, PL, Derks, EM, Faul, JD, Fitzpatrick, AL, Fohner, AE, Ford, I, Fornage, M, Gerring, Z, Grabe, HJ, Grodstein, F, Gudnason, V, Simonsick, E, Holliday, EG, Joshi, PK, Kajantie, E, Kaprio, J, Karell, P, Kleineidam, L, Knol, MJ, Kochan, NA, Kwok, JB, Leber, M, Lam, M, Lee, T, Li, S, Loukola, A, Luck, T, Marioni, RE, Mather, KA, Medland, S, Mirza, SS & Nalls, MA 2022, 'Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning', Molecular Psychiatry, vol. 27, no. 11, pp. 4419-4431. https://doi.org/10.1038/s41380-022-01710-8

TY - JOUR

T1 - Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

AU - Lahti, Jari

AU - Tuominen, Samuli

AU - Yang, Qiong

AU - Pergola, Giulio

AU - Ahmad, Shahzad

AU - Amin, Najaf

AU - Armstrong, Nicola J.

AU - Beiser, Alexa

AU - Bey, Katharina

AU - Bis, Joshua C.

AU - Boerwinkle, Eric

AU - Bressler, Jan

AU - Campbell, Archie

AU - Campbell, Harry

AU - Chen, Qiang

AU - Corley, Janie

AU - Cox, Simon R.

AU - Davies, Gail

AU - De Jager, Philip L.

AU - Derks, Eske M.

AU - Faul, Jessica D.

AU - Fitzpatrick, Annette L.

AU - Fohner, Alison E.

AU - Ford, Ian

AU - Fornage, Myriam

AU - Gerring, Zachary

AU - Grabe, Hans J.

AU - Grodstein, Francine

AU - Gudnason, Vilmundur

AU - Simonsick, Eleanor

AU - Holliday, Elizabeth G.

AU - Joshi, Peter K.

AU - Kajantie, Eero

AU - Kaprio, Jaakko

AU - Karell, Pauliina

AU - Kleineidam, Luca

AU - Knol, Maria J.

AU - Kochan, Nicole A.

AU - Kwok, John B.

AU - Leber, Markus

AU - Lam, Max

AU - Lee, Teresa

AU - Li, Shuo

AU - Loukola, Anu

AU - Luck, Tobias

AU - Marioni, Riccardo E.

AU - Mather, Karen A.

AU - Medland, Sarah

AU - Mirza, Saira S.

AU - Nalls, Mike A.

PY - 2022/8/16

Y1 - 2022/8/16

N2 - Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes.

AB - Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes.

KW - Brain

KW - Learning

KW - Memory, Short-Term/physiology

KW - Multifactorial Inheritance

KW - Verbal Learning

UR - https://www.scopus.com/pages/publications/85136173551

U2 - 10.1038/s41380-022-01710-8

DO - 10.1038/s41380-022-01710-8

M3 - Article

C2 - 35974141

SN - 1359-4184

VL - 27

SP - 4419

EP - 4431

JO - Molecular Psychiatry

JF - Molecular Psychiatry

IS - 11

ER -

Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning

Abstract

Bibliographical note

UN SDGs

Other keywords

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