Hydrogen-bonding controlled rigidity of an isoindoline-derived nitroxide spin label for nucleic acids

Dnyaneshwar B. Gophane; Snorri Th Sigurdsson

doi:10.1039/c2cc36389e

Hydrogen-bonding controlled rigidity of an isoindoline-derived nitroxide spin label for nucleic acids

Dnyaneshwar B. Gophane
, Snorri Th Sigurdsson

Faculty of Physical Sciences

University of Iceland

Research output: Contribution to journal › Article › peer-review

Abstract

Nucleosides spin-labelled with isoindoline-derived benzimidazole (^ImU) and benzoxazole (^OxU) moieties were synthesized and incorporated into DNA oligonucleotides. Both labels display limited mobility in duplex DNA but ^ImU was less mobile, which was attributed to an intramolecular hydrogen bond between the N-H of the imidazole and O4 of the uracil nucleobase.

Original language	English
Pages (from-to)	999-1001
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	10
DOIs	https://doi.org/10.1039/c2cc36389e
Publication status	Published - 3 Jan 2013

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title = "Hydrogen-bonding controlled rigidity of an isoindoline-derived nitroxide spin label for nucleic acids",

abstract = "Nucleosides spin-labelled with isoindoline-derived benzimidazole (ImU) and benzoxazole (OxU) moieties were synthesized and incorporated into DNA oligonucleotides. Both labels display limited mobility in duplex DNA but ImU was less mobile, which was attributed to an intramolecular hydrogen bond between the N-H of the imidazole and O4 of the uracil nucleobase.",

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AU - Gophane, Dnyaneshwar B.

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AB - Nucleosides spin-labelled with isoindoline-derived benzimidazole (ImU) and benzoxazole (OxU) moieties were synthesized and incorporated into DNA oligonucleotides. Both labels display limited mobility in duplex DNA but ImU was less mobile, which was attributed to an intramolecular hydrogen bond between the N-H of the imidazole and O4 of the uracil nucleobase.

UR - https://www.scopus.com/pages/publications/84872065455

U2 - 10.1039/c2cc36389e

DO - 10.1039/c2cc36389e

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JO - Chemical Communications

JF - Chemical Communications

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Hydrogen-bonding controlled rigidity of an isoindoline-derived nitroxide spin label for nucleic acids

Abstract

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