TY - JOUR
T1 - In vitro killing of Candida albicans by fatty acids and monoglycerides
AU - Bergsson, G.
AU - Arnfinnsson, J.
AU - Steingrímsson, Ó
AU - Thormar, H.
PY - 2001
Y1 - 2001
N2 - The susceptibility of Candida albicans to several fatty acids and their 1-monoglycerides was tested with a short inactivation time, and ultrathin sections were studied by transmission electron microscopy (TEM) after treatment with capric acid. The results show that capric acid, a 10-carbon saturated fatty acid, causes the fastest and most effective killing of all three strains of C. albicans tested, leaving the cytoplasm disorganized and shrunken because of a disrupted or disintegrated plasma membrane. Lauric acid, a 12-carbon saturated fatty acid, was the most active at lower concentrations and after a longer incubation time.
AB - The susceptibility of Candida albicans to several fatty acids and their 1-monoglycerides was tested with a short inactivation time, and ultrathin sections were studied by transmission electron microscopy (TEM) after treatment with capric acid. The results show that capric acid, a 10-carbon saturated fatty acid, causes the fastest and most effective killing of all three strains of C. albicans tested, leaving the cytoplasm disorganized and shrunken because of a disrupted or disintegrated plasma membrane. Lauric acid, a 12-carbon saturated fatty acid, was the most active at lower concentrations and after a longer incubation time.
UR - https://www.scopus.com/pages/publications/0034775761
U2 - 10.1128/AAC.45.11.3209-3212.2001
DO - 10.1128/AAC.45.11.3209-3212.2001
M3 - Article
C2 - 11600381
SN - 0066-4804
VL - 45
SP - 3209
EP - 3212
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 11
ER -