TY - JOUR
T1 - Localization of a gene for peripheral arterial occlusive disease to chromosome 1p31
AU - Gudmundsson, Gudmundur
AU - Matthiasson, Stefan E.
AU - Arason, Haukur
AU - Johannsson, Halldor
AU - Runarsson, Freyr
AU - Bjarnason, Hjördis
AU - Helgadottir, Katrin
AU - Thorisdottir, Steinthora
AU - Ingadottir, Gudrun
AU - Lindpaintner, Klaus
AU - Sainz, Jesus
AU - Gudnason, Vilmundur
AU - Frigge, Michael L.
AU - Kong, Augustine
AU - Gulcher, Jeffrey R.
AU - Stefansson, Kari
PY - 2002/3
Y1 - 2002/3
N2 - Peripheral arterial occlusive disease (PAOD) results from atherosclerosis of large and medium peripheral arteries, as well as the aorta, and has many risk factors, including smoking, diabetes, hypertension, and hyperlipidemia. PAOD often coexists with coronary artery disease and cerebrovascular disease. Cross-matching a population-based list of Icelandic patients with PAOD who had undergone angiography and/or revascularization procedures with a genealogy database of the entire Icelandic nation defined 116 extended families containing 272 patients. A genomewide scan with microsatellite markers revealed significant linkage to chromosome 1p31 with an allele-sharing LOD score of 3.93 (P = 1.04 × 10-5). We designate this locus as "PAOD1." Subtracting 35 patients with a history of stroke increased the LOD score to 4.93. This suggests that, although PAOD and other vascular diseases share risk factors, genetic factors specific to subtypes of vascular disease may exist.
AB - Peripheral arterial occlusive disease (PAOD) results from atherosclerosis of large and medium peripheral arteries, as well as the aorta, and has many risk factors, including smoking, diabetes, hypertension, and hyperlipidemia. PAOD often coexists with coronary artery disease and cerebrovascular disease. Cross-matching a population-based list of Icelandic patients with PAOD who had undergone angiography and/or revascularization procedures with a genealogy database of the entire Icelandic nation defined 116 extended families containing 272 patients. A genomewide scan with microsatellite markers revealed significant linkage to chromosome 1p31 with an allele-sharing LOD score of 3.93 (P = 1.04 × 10-5). We designate this locus as "PAOD1." Subtracting 35 patients with a history of stroke increased the LOD score to 4.93. This suggests that, although PAOD and other vascular diseases share risk factors, genetic factors specific to subtypes of vascular disease may exist.
UR - https://www.scopus.com/pages/publications/18244401676
U2 - 10.1086/339251
DO - 10.1086/339251
M3 - Article
C2 - 11833003
SN - 0002-9297
VL - 70
SP - 586
EP - 592
JO - American journal of human genetics
JF - American journal of human genetics
IS - 3
ER -