Lyfjaþolinn háþrýstingur – hjáhnoðuæxli: Sjúkratilfelli

Krister Blaer Jonsson; Eiríkur Orri Guðmundsson; Margrét Sigurðardóttir; Jón Jóhannes Jónsson; Helga Ágústa Sigurjónsdóttir

doi:10.17992/lbl.2023.03.735

Lyfjaþolinn háþrýstingur – hjáhnoðuæxli: Sjúkratilfelli

Translated title of the contribution: Resistant hypertension - pheochromocytoma

Krister Blaer Jonsson, Eiríkur Orri Guðmundsson, Margrét Sigurðardóttir, Jón Jóhannes Jónsson, Helga Ágústa Sigurjónsdóttir

Landspitali, University of Iceland

Research output: Contribution to journal › Article › peer-review

Abstract

Ágrip

Fjallað er um karlmann með þriggja áratuga sögu um lyfjaþolinn háþrýsting, svitaköst, hjartsláttaróþægindi og járnbragð í munni. Þrátt fyrir endurteknar komur á bráðamóttöku og uppvinnslu á göngudeild var undirliggjandi orsök ekki greind.

Síðustu þrjú árin fyrir komu hafði háþrýstingurinn versnað og viðkomandi þróað með sér sykursýki af tegund 2. Frekari uppvinnsla leiddi í ljós 3 cm hjáhnoðuæxli utan nýrans. Eftir brottnám á æxlinu er hann án lyfjameðferðar og einkennalaus.

Krómfíkla- (pheochromocytoma) og hjáhnoðuæxli (paraganglioma) eru sjaldgæf orsök háþrýstings, talin vera skýring 0,1-0,6% allra tilfella, en mikilvæg að greina vegna hættulegra fylgikvilla.

We report a case of a man with a 30-year history of treatment-resistant hypertension, hydropoiesis, tachycardic spells and dysgeusia. Despite repeated visits to the emergency department and work-up in an out-patient clinic, the diagnosis was unknown. Three years prior to remittance to an endocrinologist, the hypertension worsened, and he developed diabetes type-II. Further work-up revealed a 3 cm extra-adrenal pheochromocytoma, a paraganglioma. After surgical removal of the tumor, he is without medication and symptom free. Pheochromocytoma and paraganglioma are rare causes of hypertension, estimated to explain 0.1-0.6% of all cases, but nonetheless an important diagnosis to make, due to serious side effects.

Translated title of the contribution	Resistant hypertension - pheochromocytoma
Original language	Icelandic
Pages (from-to)	141-145
Number of pages	5
Journal	Læknablaðið
Volume	109
Issue number	3
DOIs	https://doi.org/10.17992/lbl.2023.03.735
Publication status	Published - 1 Mar 2023

Bibliographical note

Other keywords

metanephrine
neuroendocrine tumor
paraganglioma
pheochromocytoma
resistant hypertension

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.17992/lbl.2023.03.735

Cite this

@article{af6426c724cf46869402d06d65085c75,

title = "Lyfja{\th}olinn h{\'a}{\th}r{\'y}stingur – hj{\'a}hno{\dh}u{\ae}xli: Sj{\'u}kratilfelli",

abstract = "{\'A}gripFjalla{\dh} er um karlmann me{\dh} {\th}riggja {\'a}ratuga s{\"o}gu um lyfja{\th}olinn h{\'a}{\th}r{\'y}sting, svitak{\"o}st, hjartsl{\'a}ttar{\'o}{\th}{\ae}gindi og j{\'a}rnbrag{\dh} {\'i} munni. {\TH}r{\'a}tt fyrir endurteknar komur {\'a} br{\'a}{\dh}am{\'o}tt{\"o}ku og uppvinnslu {\'a} g{\"o}ngudeild var undirliggjandi ors{\"o}k ekki greind.S{\'i}{\dh}ustu {\th}rj{\'u} {\'a}rin fyrir komu haf{\dh}i h{\'a}{\th}r{\'y}stingurinn versna{\dh} og vi{\dh}komandi {\th}r{\'o}a{\dh} me{\dh} s{\'e}r sykurs{\'y}ki af tegund 2. Frekari uppvinnsla leiddi {\'i} lj{\'o}s 3 cm hj{\'a}hno{\dh}u{\ae}xli utan n{\'y}rans. Eftir brottn{\'a}m {\'a} {\ae}xlinu er hann {\'a}n lyfjame{\dh}fer{\dh}ar og einkennalaus.Kr{\'o}mf{\'i}kla- (pheochromocytoma) og hj{\'a}hno{\dh}u{\ae}xli (paraganglioma) eru sjaldg{\ae}f ors{\"o}k h{\'a}{\th}r{\'y}stings, talin vera sk{\'y}ring 0,1-0,6\% allra tilfella, en mikilv{\ae}g a{\dh} greina vegna h{\ae}ttulegra fylgikvilla.We report a case of a man with a 30-year history of treatment-resistant hypertension, hydropoiesis, tachycardic spells and dysgeusia. Despite repeated visits to the emergency department and work-up in an out-patient clinic, the diagnosis was unknown. Three years prior to remittance to an endocrinologist, the hypertension worsened, and he developed diabetes type-II. Further work-up revealed a 3 cm extra-adrenal pheochromocytoma, a paraganglioma. After surgical removal of the tumor, he is without medication and symptom free. Pheochromocytoma and paraganglioma are rare causes of hypertension, estimated to explain 0.1-0.6\% of all cases, but nonetheless an important diagnosis to make, due to serious side effects.",

keywords = "Adrenal Gland Neoplasms, Ambulatory Care Facilities, Humans, Hypertension, Male, Paraganglioma, Pheochromocytoma, metanephrine, neuroendocrine tumor, paraganglioma, pheochromocytoma, resistant hypertension, metanephrine, neuroendocrine tumor, paraganglioma, pheochromocytoma, resistant hypertension",

author = "Jonsson, \{Krister Blaer\} and Gu{\dh}mundsson, \{Eir{\'i}kur Orri\} and Margr{\'e}t Sigur{\dh}ard{\'o}ttir and J{\'o}nsson, \{J{\'o}n J{\'o}hannes\} and Sigurj{\'o}nsd{\'o}ttir, \{Helga {\'A}g{\'u}sta\}",

year = "2023",

month = mar,

day = "1",

doi = "10.17992/lbl.2023.03.735",

language = "{\'I}slenska",

volume = "109",

pages = "141--145",

journal = "L{\ae}knabla{\dh}i{\dh}",

issn = "1670-4959",

publisher = "Icelandic Medical Association",

number = "3",

}

TY - JOUR

T1 - Lyfjaþolinn háþrýstingur – hjáhnoðuæxli

T2 - Sjúkratilfelli

AU - Jonsson, Krister Blaer

AU - Guðmundsson, Eiríkur Orri

AU - Sigurðardóttir, Margrét

AU - Jónsson, Jón Jóhannes

AU - Sigurjónsdóttir, Helga Ágústa

PY - 2023/3/1

Y1 - 2023/3/1

N2 - ÁgripFjallað er um karlmann með þriggja áratuga sögu um lyfjaþolinn háþrýsting, svitaköst, hjartsláttaróþægindi og járnbragð í munni. Þrátt fyrir endurteknar komur á bráðamóttöku og uppvinnslu á göngudeild var undirliggjandi orsök ekki greind.Síðustu þrjú árin fyrir komu hafði háþrýstingurinn versnað og viðkomandi þróað með sér sykursýki af tegund 2. Frekari uppvinnsla leiddi í ljós 3 cm hjáhnoðuæxli utan nýrans. Eftir brottnám á æxlinu er hann án lyfjameðferðar og einkennalaus.Krómfíkla- (pheochromocytoma) og hjáhnoðuæxli (paraganglioma) eru sjaldgæf orsök háþrýstings, talin vera skýring 0,1-0,6% allra tilfella, en mikilvæg að greina vegna hættulegra fylgikvilla.We report a case of a man with a 30-year history of treatment-resistant hypertension, hydropoiesis, tachycardic spells and dysgeusia. Despite repeated visits to the emergency department and work-up in an out-patient clinic, the diagnosis was unknown. Three years prior to remittance to an endocrinologist, the hypertension worsened, and he developed diabetes type-II. Further work-up revealed a 3 cm extra-adrenal pheochromocytoma, a paraganglioma. After surgical removal of the tumor, he is without medication and symptom free. Pheochromocytoma and paraganglioma are rare causes of hypertension, estimated to explain 0.1-0.6% of all cases, but nonetheless an important diagnosis to make, due to serious side effects.

AB - ÁgripFjallað er um karlmann með þriggja áratuga sögu um lyfjaþolinn háþrýsting, svitaköst, hjartsláttaróþægindi og járnbragð í munni. Þrátt fyrir endurteknar komur á bráðamóttöku og uppvinnslu á göngudeild var undirliggjandi orsök ekki greind.Síðustu þrjú árin fyrir komu hafði háþrýstingurinn versnað og viðkomandi þróað með sér sykursýki af tegund 2. Frekari uppvinnsla leiddi í ljós 3 cm hjáhnoðuæxli utan nýrans. Eftir brottnám á æxlinu er hann án lyfjameðferðar og einkennalaus.Krómfíkla- (pheochromocytoma) og hjáhnoðuæxli (paraganglioma) eru sjaldgæf orsök háþrýstings, talin vera skýring 0,1-0,6% allra tilfella, en mikilvæg að greina vegna hættulegra fylgikvilla.We report a case of a man with a 30-year history of treatment-resistant hypertension, hydropoiesis, tachycardic spells and dysgeusia. Despite repeated visits to the emergency department and work-up in an out-patient clinic, the diagnosis was unknown. Three years prior to remittance to an endocrinologist, the hypertension worsened, and he developed diabetes type-II. Further work-up revealed a 3 cm extra-adrenal pheochromocytoma, a paraganglioma. After surgical removal of the tumor, he is without medication and symptom free. Pheochromocytoma and paraganglioma are rare causes of hypertension, estimated to explain 0.1-0.6% of all cases, but nonetheless an important diagnosis to make, due to serious side effects.

KW - Adrenal Gland Neoplasms

KW - Ambulatory Care Facilities

KW - Humans

KW - Hypertension

KW - Male

KW - Paraganglioma

KW - Pheochromocytoma

KW - metanephrine

KW - neuroendocrine tumor

KW - paraganglioma

KW - pheochromocytoma

KW - resistant hypertension

KW - metanephrine

KW - neuroendocrine tumor

KW - paraganglioma

KW - pheochromocytoma

KW - resistant hypertension

UR - https://www.scopus.com/pages/publications/85149427688

U2 - 10.17992/lbl.2023.03.735

DO - 10.17992/lbl.2023.03.735

M3 - Grein

C2 - 36856470

SN - 1670-4959

VL - 109

SP - 141

EP - 145

JO - Læknablaðið

JF - Læknablaðið

IS - 3

ER -

Lyfjaþolinn háþrýstingur – hjáhnoðuæxli: Sjúkratilfelli

Abstract

Bibliographical note

Other keywords

UN SDGs

Access to Document

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Cite this