Measles virus-specific immunoglobulin D antibody in cerebrospinal fluid and serum from patients with subacute sclerosing panencephalitis and multiple sclerosis

B. A. Patrick; P. D. Mehta; W. Sobczyk; J. Kulczycki; J. Woyciechowska-Camenga; D. Camenga; H. Thormar

doi:10.1016/0165-5728(90)90121-3

Measles virus-specific immunoglobulin D antibody in cerebrospinal fluid and serum from patients with subacute sclerosing panencephalitis and multiple sclerosis

B. A. Patrick, P. D. Mehta, W. Sobczyk, J. Kulczycki, J. Woyciechowska-Camenga, D. Camenga, H. Thormar

Faculty of Life and Environmental Sciences

University of Iceland

Research output: Contribution to journal › Article › peer-review

Abstract

Quantitation of measles-specific immunoglobulin D (IgD) antibody was carried out in cerebrospinal fluid (CSF) and serum samples from 18 patients with subacute sclerosing panencephalitis (SSPE), 12 patients with multiple sclerosis (MS) and seven normal controls with high measles antibody titers in serum, using polyclonal and monoclonal antibodies specific for human IgD and enzyme-linked immunosorbent assay. Measles-specific IgD activity was significantly higher in CSF and serum from SSPE patients compared to that found in patients with MS or normal controls. The IgD antibody to measles virus was not due to high levels of measles-specific IgG since significant measles IgD activity was found after eluting IgG from SSPE serum. The increased level of measles-specific IgD found in SSPE sera is consistent with the levels observed in patients with acute and chronic viral infections.

Original language	English
Pages (from-to)	69-74
Number of pages	6
Journal	Journal of Neuroimmunology
Volume	26
Issue number	1
DOIs	https://doi.org/10.1016/0165-5728(90)90121-3
Publication status	Published - Jan 1990

Other keywords

Cerebrospinal fluid
Enzyme-linked immunosorbent assay
Immunoglobulin D
Measles virus
Multiple sclerosis
Subacute sclerosing panencephalitis

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10.1016/0165-5728(90)90121-3

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@article{35ba78a351e94ca4941dc8f3e021b279,

title = "Measles virus-specific immunoglobulin D antibody in cerebrospinal fluid and serum from patients with subacute sclerosing panencephalitis and multiple sclerosis",

abstract = "Quantitation of measles-specific immunoglobulin D (IgD) antibody was carried out in cerebrospinal fluid (CSF) and serum samples from 18 patients with subacute sclerosing panencephalitis (SSPE), 12 patients with multiple sclerosis (MS) and seven normal controls with high measles antibody titers in serum, using polyclonal and monoclonal antibodies specific for human IgD and enzyme-linked immunosorbent assay. Measles-specific IgD activity was significantly higher in CSF and serum from SSPE patients compared to that found in patients with MS or normal controls. The IgD antibody to measles virus was not due to high levels of measles-specific IgG since significant measles IgD activity was found after eluting IgG from SSPE serum. The increased level of measles-specific IgD found in SSPE sera is consistent with the levels observed in patients with acute and chronic viral infections.",

keywords = "Cerebrospinal fluid, Enzyme-linked immunosorbent assay, Immunoglobulin D, Measles virus, Multiple sclerosis, Subacute sclerosing panencephalitis",

author = "Patrick, \{B. A.\} and Mehta, \{P. D.\} and W. Sobczyk and J. Kulczycki and J. Woyciechowska-Camenga and D. Camenga and H. Thormar",

year = "1990",

month = jan,

doi = "10.1016/0165-5728(90)90121-3",

language = "English",

volume = "26",

pages = "69--74",

journal = "Journal of Neuroimmunology",

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T1 - Measles virus-specific immunoglobulin D antibody in cerebrospinal fluid and serum from patients with subacute sclerosing panencephalitis and multiple sclerosis

AU - Patrick, B. A.

AU - Mehta, P. D.

AU - Sobczyk, W.

AU - Kulczycki, J.

AU - Woyciechowska-Camenga, J.

AU - Camenga, D.

AU - Thormar, H.

PY - 1990/1

Y1 - 1990/1

N2 - Quantitation of measles-specific immunoglobulin D (IgD) antibody was carried out in cerebrospinal fluid (CSF) and serum samples from 18 patients with subacute sclerosing panencephalitis (SSPE), 12 patients with multiple sclerosis (MS) and seven normal controls with high measles antibody titers in serum, using polyclonal and monoclonal antibodies specific for human IgD and enzyme-linked immunosorbent assay. Measles-specific IgD activity was significantly higher in CSF and serum from SSPE patients compared to that found in patients with MS or normal controls. The IgD antibody to measles virus was not due to high levels of measles-specific IgG since significant measles IgD activity was found after eluting IgG from SSPE serum. The increased level of measles-specific IgD found in SSPE sera is consistent with the levels observed in patients with acute and chronic viral infections.

AB - Quantitation of measles-specific immunoglobulin D (IgD) antibody was carried out in cerebrospinal fluid (CSF) and serum samples from 18 patients with subacute sclerosing panencephalitis (SSPE), 12 patients with multiple sclerosis (MS) and seven normal controls with high measles antibody titers in serum, using polyclonal and monoclonal antibodies specific for human IgD and enzyme-linked immunosorbent assay. Measles-specific IgD activity was significantly higher in CSF and serum from SSPE patients compared to that found in patients with MS or normal controls. The IgD antibody to measles virus was not due to high levels of measles-specific IgG since significant measles IgD activity was found after eluting IgG from SSPE serum. The increased level of measles-specific IgD found in SSPE sera is consistent with the levels observed in patients with acute and chronic viral infections.

KW - Cerebrospinal fluid

KW - Enzyme-linked immunosorbent assay

KW - Immunoglobulin D

KW - Measles virus

KW - Multiple sclerosis

KW - Subacute sclerosing panencephalitis

UR - https://www.scopus.com/pages/publications/0025171880

U2 - 10.1016/0165-5728(90)90121-3

DO - 10.1016/0165-5728(90)90121-3

M3 - Article

C2 - 2294143

SN - 0165-5728

VL - 26

SP - 69

EP - 74

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1

ER -

Measles virus-specific immunoglobulin D antibody in cerebrospinal fluid and serum from patients with subacute sclerosing panencephalitis and multiple sclerosis

Abstract

Other keywords

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