@inproceedings{d6570f2b378d498c8306e5709bf85d21,
title = "Modelling the release of moxifloxacin from plasma grafted intraocular lenses with rotational symmetric numerical framework",
abstract = "A rotational symmetric finite element model is constructed to simulate the release of moxifloxacin from different types of plasma-grafted intraocular lenses, utilizing general discontinuous boundary conditions to describe the interface between lens and outside medium. Such boundary conditions allow for the modelling of partitioning and interfacial mass transfer resistance. Due to its rotational symmetry, the shape of the optical part of the intraocular lens is fully taken into account. Two types of polyacrylates were plasma-grafted to the intraocular lens to act as barriers for the release of the loaded drug. Simulations are carried out and compared to release experiments to infer drug-material properties, which is crucial for optimising therapeutic effects.",
keywords = "Discontinuities, Finite element, Mass transfer, Ocular drug delivery, Partitioning, Plasma-grafting, Targeted drug delivery",
author = "Kristinn Gudnason and Sven Sigurdsson and Fjola Jonsdottir and Guiomar, \{A. J.\} and Vieira, \{A. P.\} and P. Alves and P. Coimbra and Gil, \{M. H.\}",
note = "Publisher Copyright: {\textcopyright} 2018, Springer International Publishing AG, part of Springer Nature.; 6th International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2018 ; Conference date: 25-04-2018 Through 27-04-2018",
year = "2018",
doi = "10.1007/978-3-319-78723-7\_28",
language = "English",
isbn = "9783319787220",
series = "Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)",
publisher = "Springer Verlag",
pages = "329--339",
editor = "Ignacio Rojas and Francisco Ortuno",
booktitle = "Bioinformatics and Biomedical Engineering - 6th International Work-Conference, IWBBIO 2018, Proceedings",
address = "Germany",
}