Abstract
Rabbits were immunized with herpes simplex and visna virus in complete Freund's adjuvant. Uv-inactivated herpes virus and the purified visna virus protein p 25 injected intraocularly into these rabbits elicited a moderate inflammatory cell infiltration in the epiretinal myelinated nerve fiber bundles accompanied by signs of demyelination. It is therefore apparent that also viral antigen can induce myelin lesions as a socalled "bystander effect" of a cell-mediated immune response (bystander demyelination).
| Original language | English |
|---|---|
| Pages (from-to) | 215-217 |
| Number of pages | 3 |
| Journal | Acta Neuropathologica |
| Volume | 48 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jan 1979 |
Other keywords
- Demyelination
- Herpes simplex virus
- Visna virus
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