TY - JOUR
T1 - New genetic loci link adipose and insulin biology to body fat distribution
AU - Et al.
AU - Guðnason, Vilmundur G
AU - Thorsteinsdottir, Unnur
AU - Þorgeirsson, Guðmundur
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P
AB - Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P
UR - https://europepmc.org/articles/PMC4338562
U2 - 10.1038/nature14132
DO - 10.1038/nature14132
M3 - Grein
C2 - 25673412
SN - 0028-0836
VL - 518
SP - 187
EP - 196
JO - Nature
JF - Nature
ER -