TY - GEN
T1 - Numerical modeling of controlled release of drugs from silicone elastomers
AU - Jonsdottir, Fjola
AU - Gudmundsdottir, Rut
AU - Sigurdsson, Sven Th
AU - Snorradottir, Bergthora S.
AU - Mar, Masson
PY - 2011
Y1 - 2011
N2 - Silicone based medical devices, where the function is enhanced by the release of a drug or other bioactive compound, are of interest for a variety of applications. Such a device must release the drug at a given rate over a given period of time, while maintaining the shape and material properties required for the primary function of the device. Achieving these goals in an optimal fashion is challenging if one relies solely on traditional experimental work. Accurate numerical modeling compliments experimentation by allowing fast evaluation of parameters and subsequent validation of a select set of promising cases. Our ultimate goal is a numerical model which can accurately predict drug release characteristics from silicone elastomers with complicated geometry and inhomogeneous drug dispersion. In this work, we lay the foundations for such a comprehensive model. We describe a numerical model for simple geometries and carry out a parametric study for various initial and boundary conditions. We validate our modeling work by comparison with experimental trials, carried out by our own group. The work is carried out in a group composed of engineers and pharmaceutical scientists, ensuring step-by-step validation of models against experimental results.
AB - Silicone based medical devices, where the function is enhanced by the release of a drug or other bioactive compound, are of interest for a variety of applications. Such a device must release the drug at a given rate over a given period of time, while maintaining the shape and material properties required for the primary function of the device. Achieving these goals in an optimal fashion is challenging if one relies solely on traditional experimental work. Accurate numerical modeling compliments experimentation by allowing fast evaluation of parameters and subsequent validation of a select set of promising cases. Our ultimate goal is a numerical model which can accurately predict drug release characteristics from silicone elastomers with complicated geometry and inhomogeneous drug dispersion. In this work, we lay the foundations for such a comprehensive model. We describe a numerical model for simple geometries and carry out a parametric study for various initial and boundary conditions. We validate our modeling work by comparison with experimental trials, carried out by our own group. The work is carried out in a group composed of engineers and pharmaceutical scientists, ensuring step-by-step validation of models against experimental results.
UR - https://www.scopus.com/pages/publications/84859548997
U2 - 10.1115/smasis2011-4957
DO - 10.1115/smasis2011-4957
M3 - Conference contribution
SN - 9780791854716
T3 - ASME 2011 Conference on Smart Materials, Adaptive Structures and Intelligent Systems, SMASIS 2011
SP - 39
EP - 44
BT - ASME 2011 Conference on Smart Materials, Adaptive Structures and Intelligent Systems, SMASIS 2011
PB - The American Society of Mechanical Engineers(ASME)
T2 - ASME 2011 Conference on Smart Materials, Adaptive Structures and Intelligent Systems, SMASIS 2011
Y2 - 18 September 2011 through 21 September 2011
ER -