TY - JOUR
T1 - Oxygen saturation in central retinal vein occlusion
AU - Hardarson, Sveinn Hakon
AU - Stefnsson, Einar
N1 - Funding Information: Publication of this article was supported by the Icelandic Center for Research (Rannís), Eimskip University Fund , University of Iceland Research Fund , Landspítali-University Hospital Research Fund , and Helga Jónsdóttir and Sigurliði Kristjánsson Memorial Fund - all located in Reykjavik, Iceland. The authors own stock in the company that developed and supplied the retinal oximeter used (Oxymap ehf). Sveinn Hakon Hardarson is partly employed by Oxymap ehf. The authors are co-applicants on US patent application no. 11/146,278. Both authors were involved in design and conduct of the study; collection of data; management of data; analysis and interpretation of data; and preparation, review, and approval of the manuscript. The study was approved by the National Bioethics Committee of Iceland and The Icelandic Data Protection Authority. Patients signed informed consent for participating in the study.
PY - 2010/12
Y1 - 2010/12
N2 - Purpose: To test whether oxygen saturation is affected in retinal blood vessels in patients with central retinal vein occlusion (CRVO). Design: Prospective observational case series. Methods: Oxygen saturation of hemoglobin was measured in retinal blood vessels in 10 patients with unilateral CRVO. The duration of CRVO before measurement was from 1 day to about 6 months. Two patients were excluded because of poor quality of oximetry images. The spectrophotometric retinal oximeter is based on a fundus camera. It simultaneously captures images of the retina at 605 nm and 586 nm and calculates optical density (absorbance) of retinal vessels at both wavelengths. The ratio of the 2 optical densities is approximately linearly related to hemoglobin oxygen saturation. Mean oxygen saturation was calculated for first- and second-degree arterioles and venules in both eyes of each patient. Results: The mean oxygen saturation of hemoglobin in retinal venules was 49% ± 12% (mean ± SD, n = 8) in eyes affected by CRVO and 65% ± 6% in unaffected fellow eyes (P = .003). The mean arteriolar oxygen saturation was 99% ± 3% in CRVO eyes and 99% ± 6% in the fellow eyes. Venular oxygen saturation was variable within and between CRVO eyes. Conclusions: Oxygen saturation in retinal venules is lower in eyes with CRVO than in fellow eyes and there is considerable variability within and between CRVO eyes. Arteriolar saturation is the same in CRVO and fellow eyes. Retinal oxygenation is disturbed in CRVO.
AB - Purpose: To test whether oxygen saturation is affected in retinal blood vessels in patients with central retinal vein occlusion (CRVO). Design: Prospective observational case series. Methods: Oxygen saturation of hemoglobin was measured in retinal blood vessels in 10 patients with unilateral CRVO. The duration of CRVO before measurement was from 1 day to about 6 months. Two patients were excluded because of poor quality of oximetry images. The spectrophotometric retinal oximeter is based on a fundus camera. It simultaneously captures images of the retina at 605 nm and 586 nm and calculates optical density (absorbance) of retinal vessels at both wavelengths. The ratio of the 2 optical densities is approximately linearly related to hemoglobin oxygen saturation. Mean oxygen saturation was calculated for first- and second-degree arterioles and venules in both eyes of each patient. Results: The mean oxygen saturation of hemoglobin in retinal venules was 49% ± 12% (mean ± SD, n = 8) in eyes affected by CRVO and 65% ± 6% in unaffected fellow eyes (P = .003). The mean arteriolar oxygen saturation was 99% ± 3% in CRVO eyes and 99% ± 6% in the fellow eyes. Venular oxygen saturation was variable within and between CRVO eyes. Conclusions: Oxygen saturation in retinal venules is lower in eyes with CRVO than in fellow eyes and there is considerable variability within and between CRVO eyes. Arteriolar saturation is the same in CRVO and fellow eyes. Retinal oxygenation is disturbed in CRVO.
UR - https://www.scopus.com/pages/publications/78649491244
U2 - 10.1016/j.ajo.2010.06.020
DO - 10.1016/j.ajo.2010.06.020
M3 - Article
C2 - 20875633
SN - 0002-9394
VL - 150
SP - 871
EP - 875
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 6
ER -