Prevalence and Risk Factors for Cornea Guttata in the Reykjavik Eye Study

Gunnar M. Zoega; Aya Fujisawa; Hiroshi Sasaki; Akiko Kubota; Kazuyuki Sasaki; Kazuko Kitagawa; Fridbert Jonasson

doi:10.1016/j.ophtha.2005.12.014

Prevalence and Risk Factors for Cornea Guttata in the Reykjavik Eye Study

Gunnar M. Zoega, Aya Fujisawa, Hiroshi Sasaki, Akiko Kubota, Kazuyuki Sasaki, Kazuko Kitagawa, Fridbert Jonasson

Faculty of Medicine

University of Iceland

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To establish the age- and gender-specific prevalence of cornea guttata (CG) in citizens of Reykjavik, Iceland, 55 years and older. Design: Cross-sectional, random, population-based study. Participants: The 774 participants were those participating in the second examination of the Reykjavik Eye Study. At baseline, we had a response rate of 75.8%, and at the 5-year follow-up, 88% of the survivors participated. Methods: We used slit-lamp and non-contact specular microscopy and endothelial specular photography as well as computer-assisted morphometry. We used a standardized grading system for CG. Main Outcome Measures: Diagnosis of primary central CG. Results: The prevalence of CG is 11% for females and 7% for males both for right eyes and left eyes. Higher weight and higher body mass index are found to be associated with decreased risk of CG. Having smoked more than 20 pack-years increased the risk of CG more than 2-fold (P<0.02). Conclusions: Cornea guttata seem to be found more commonly in women than in men. Smoking for more than 20 pack-years increases the risk of developing CG more than 2-fold.

Original language	English
Pages (from-to)	565-569
Number of pages	5
Journal	Ophthalmology
Volume	113
Issue number	4
DOIs	https://doi.org/10.1016/j.ophtha.2005.12.014
Publication status	Published - Apr 2006

Bibliographical note

Funding Information: Supported by St. Joseph’s Hospital Landakot Foundation, Reykjavik, Iceland; University National Hospital Research Fund, Reykjavik, Iceland; University of Iceland (Reykjavik, Iceland) Research Grant; and the Helga Jonsdottir and Sigurlidi Kristjansson Memorial Research Fund, Reykjavik, Iceland.

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10.1016/j.ophtha.2005.12.014

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@article{35fdb1c98c104d81b980e413a50f7f65,

title = "Prevalence and Risk Factors for Cornea Guttata in the Reykjavik Eye Study",

abstract = "Purpose: To establish the age- and gender-specific prevalence of cornea guttata (CG) in citizens of Reykjavik, Iceland, 55 years and older. Design: Cross-sectional, random, population-based study. Participants: The 774 participants were those participating in the second examination of the Reykjavik Eye Study. At baseline, we had a response rate of 75.8\%, and at the 5-year follow-up, 88\% of the survivors participated. Methods: We used slit-lamp and non-contact specular microscopy and endothelial specular photography as well as computer-assisted morphometry. We used a standardized grading system for CG. Main Outcome Measures: Diagnosis of primary central CG. Results: The prevalence of CG is 11\% for females and 7\% for males both for right eyes and left eyes. Higher weight and higher body mass index are found to be associated with decreased risk of CG. Having smoked more than 20 pack-years increased the risk of CG more than 2-fold (P<0.02). Conclusions: Cornea guttata seem to be found more commonly in women than in men. Smoking for more than 20 pack-years increases the risk of developing CG more than 2-fold.",

author = "Zoega, \{Gunnar M.\} and Aya Fujisawa and Hiroshi Sasaki and Akiko Kubota and Kazuyuki Sasaki and Kazuko Kitagawa and Fridbert Jonasson",

note = "Funding Information: Supported by St. Joseph{\textquoteright}s Hospital Landakot Foundation, Reykjavik, Iceland; University National Hospital Research Fund, Reykjavik, Iceland; University of Iceland (Reykjavik, Iceland) Research Grant; and the Helga Jonsdottir and Sigurlidi Kristjansson Memorial Research Fund, Reykjavik, Iceland.",

year = "2006",

month = apr,

doi = "10.1016/j.ophtha.2005.12.014",

language = "English",

volume = "113",

pages = "565--569",

journal = "Ophthalmology",

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T1 - Prevalence and Risk Factors for Cornea Guttata in the Reykjavik Eye Study

AU - Zoega, Gunnar M.

AU - Fujisawa, Aya

AU - Sasaki, Hiroshi

AU - Kubota, Akiko

AU - Sasaki, Kazuyuki

AU - Kitagawa, Kazuko

AU - Jonasson, Fridbert

N1 - Funding Information: Supported by St. Joseph’s Hospital Landakot Foundation, Reykjavik, Iceland; University National Hospital Research Fund, Reykjavik, Iceland; University of Iceland (Reykjavik, Iceland) Research Grant; and the Helga Jonsdottir and Sigurlidi Kristjansson Memorial Research Fund, Reykjavik, Iceland.

PY - 2006/4

Y1 - 2006/4

N2 - Purpose: To establish the age- and gender-specific prevalence of cornea guttata (CG) in citizens of Reykjavik, Iceland, 55 years and older. Design: Cross-sectional, random, population-based study. Participants: The 774 participants were those participating in the second examination of the Reykjavik Eye Study. At baseline, we had a response rate of 75.8%, and at the 5-year follow-up, 88% of the survivors participated. Methods: We used slit-lamp and non-contact specular microscopy and endothelial specular photography as well as computer-assisted morphometry. We used a standardized grading system for CG. Main Outcome Measures: Diagnosis of primary central CG. Results: The prevalence of CG is 11% for females and 7% for males both for right eyes and left eyes. Higher weight and higher body mass index are found to be associated with decreased risk of CG. Having smoked more than 20 pack-years increased the risk of CG more than 2-fold (P<0.02). Conclusions: Cornea guttata seem to be found more commonly in women than in men. Smoking for more than 20 pack-years increases the risk of developing CG more than 2-fold.

AB - Purpose: To establish the age- and gender-specific prevalence of cornea guttata (CG) in citizens of Reykjavik, Iceland, 55 years and older. Design: Cross-sectional, random, population-based study. Participants: The 774 participants were those participating in the second examination of the Reykjavik Eye Study. At baseline, we had a response rate of 75.8%, and at the 5-year follow-up, 88% of the survivors participated. Methods: We used slit-lamp and non-contact specular microscopy and endothelial specular photography as well as computer-assisted morphometry. We used a standardized grading system for CG. Main Outcome Measures: Diagnosis of primary central CG. Results: The prevalence of CG is 11% for females and 7% for males both for right eyes and left eyes. Higher weight and higher body mass index are found to be associated with decreased risk of CG. Having smoked more than 20 pack-years increased the risk of CG more than 2-fold (P<0.02). Conclusions: Cornea guttata seem to be found more commonly in women than in men. Smoking for more than 20 pack-years increases the risk of developing CG more than 2-fold.

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ER -

Prevalence and Risk Factors for Cornea Guttata in the Reykjavik Eye Study

Abstract

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