TY - JOUR
T1 - Progression of traction bronchiectasis/bronchiolectasis in interstitial lung abnormalities is associated with increased all-cause mortality
T2 - Age Gene/Environment Susceptibility-Reykjavik Study
AU - Hino, Takuya
AU - Hida, Tomoyuki
AU - Nishino, Mizuki
AU - Lu, Junwei
AU - Putman, Rachel K.
AU - Guðmundsson, Elías Freyr
AU - Hata, Akinori
AU - Araki, Tetsuro
AU - Valtchinov, Vladimir I.
AU - Honda, Osamu
AU - Yanagawa, Masahiro
AU - Yamada, Yoshitake
AU - Kamitani, Takeshi
AU - Jinzaki, Masahiro
AU - Tomiyama, Noriyuki
AU - Ishigami, Kousei
AU - Honda, Hiroshi
AU - San Jose Estepar, Raul
AU - Washko, George R.
AU - Johkoh, Takeshi
AU - Christiani, David C.
AU - Lynch, David A.
AU - Guðnason, Vilmundur G.
AU - Guðmundsson, Gunnar
AU - Hunninghake, Gary M.
AU - Hatabu, Hiroto
N1 - Funding text Dr. Nishino reports personal fees from Daiichi Sankyo, from AstraZeneca, grants from Merck investigator studies program, grants from Canon Medical Systems, grants from AstraZeneca, grants from Daiichi Sankyo, personal fees from Roche, outside the submitted work. Publisher Copyright: © 2021 The Author(s)
PY - 2021/3/10
Y1 - 2021/3/10
N2 - Purpose: The aim of this study is to assess the role of traction bronchiectasis/bronchiolectasis and its progression as a predictor for early fibrosis in interstitial lung abnormalities (ILA).Methods: Three hundred twenty-seven ILA participants out of 5764 in the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study who had undergone chest CT twice with an interval of approximately five-years were enrolled in this study. Traction bronchiectasis/bronchiolectasis index (TBI) was classified on a four-point scale: 0, ILA without traction bronchiectasis/bronchiolectasis; 1, ILA with bronchiolectasis but without bronchiectasis or architectural distortion; 2, ILA with mild to moderate traction bronchiectasis; 3, ILA and severe traction bronchiectasis and/or honeycombing. Traction bronchiectasis (TB) progression was classified on a five-point scale: 1, Improved; 2, Probably improved; 3, No change; 4, Probably progressed; 5, Progressed. Overall survival (OS) among participants with different TB Progression Score and between the TB progression group and No TB progression group was also investigated. Hazard radio (HR) was estimated with Cox proportional hazards model.Results: The higher the TBI at baseline, the higher TB Progression Score (P < 0.001). All five participants with TBI = 3 at baseline progressed; 46 (90 %) of 51 participants with TBI = 2 progressed. TB progression was also associated with shorter OS with statistically significant difference (adjusted HR = 1.68, P < 0.001).Conclusion: TB progression was visualized on chest CT frequently and clearly. It has the potential to be the predictor for poorer prognosis of ILA.
AB - Purpose: The aim of this study is to assess the role of traction bronchiectasis/bronchiolectasis and its progression as a predictor for early fibrosis in interstitial lung abnormalities (ILA).Methods: Three hundred twenty-seven ILA participants out of 5764 in the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study who had undergone chest CT twice with an interval of approximately five-years were enrolled in this study. Traction bronchiectasis/bronchiolectasis index (TBI) was classified on a four-point scale: 0, ILA without traction bronchiectasis/bronchiolectasis; 1, ILA with bronchiolectasis but without bronchiectasis or architectural distortion; 2, ILA with mild to moderate traction bronchiectasis; 3, ILA and severe traction bronchiectasis and/or honeycombing. Traction bronchiectasis (TB) progression was classified on a five-point scale: 1, Improved; 2, Probably improved; 3, No change; 4, Probably progressed; 5, Progressed. Overall survival (OS) among participants with different TB Progression Score and between the TB progression group and No TB progression group was also investigated. Hazard radio (HR) was estimated with Cox proportional hazards model.Results: The higher the TBI at baseline, the higher TB Progression Score (P < 0.001). All five participants with TBI = 3 at baseline progressed; 46 (90 %) of 51 participants with TBI = 2 progressed. TB progression was also associated with shorter OS with statistically significant difference (adjusted HR = 1.68, P < 0.001).Conclusion: TB progression was visualized on chest CT frequently and clearly. It has the potential to be the predictor for poorer prognosis of ILA.
KW - Age Gene/Environment Susceptibility-Reykjavik Study
KW - Interstitial lung abnormality
KW - Pulmonary fibrosis
KW - Traction bronchiectasis
KW - Usual interstitial pneumonia
UR - http://www.scopus.com/inward/record.url?scp=85102121582&partnerID=8YFLogxK
U2 - 10.1016/j.ejro.2021.100334
DO - 10.1016/j.ejro.2021.100334
M3 - Article
C2 - 33748349
SN - 2352-0477
VL - 8
SP - 100334
JO - European Journal of Radiology Open
JF - European Journal of Radiology Open
M1 - 100334
ER -
