Spirometric patterns in young and middle-aged adults: A 20-year European study

Anne Elie Carsin; Judith Garcia-Aymerich; Simone Accordini; Shyamali Dharmage; Bénédicte Leynaert; Marti De Las Heras; Lidia Casas; Seraina Caviezel; Pascal Demoly; Bertil Forsberg; Þórarinn Gíslason; Angelo Guido Corsico; Christer Janson; Rain Jogi; Jesús Martínez-Moratalla; Dennis Nowak; Leopoldo Palacios Gómez; Isabelle Pin; Nicole Probst-Hensch; Chantal Raherison-Semjen; Giulia Squillacioti; Cecilie Svanes; Kjell Torén; Isabel Urrutia; Ismael Huerta; Josep Maria Anto; Debbie Jarvis; Stefano Guerra

doi:10.1136/thorax-2022-219696

Spirometric patterns in young and middle-aged adults: A 20-year European study

Anne Elie Carsin
, Judith Garcia-Aymerich
, Simone Accordini
, Shyamali Dharmage
, Bénédicte Leynaert
, Marti De Las Heras
, Lidia Casas
, Seraina Caviezel
, Pascal Demoly
, Bertil Forsberg
, Þórarinn Gíslason
, Angelo Guido Corsico
, Christer Janson
, Rain Jogi
, Jesús Martínez-Moratalla
, Dennis Nowak
, Leopoldo Palacios Gómez
, Isabelle Pin
, Nicole Probst-Hensch
, Chantal Raherison-Semjen

Giulia Squillacioti, Cecilie Svanes, Kjell Torén, Isabel Urrutia, Ismael Huerta, Josep Maria Anto, Debbie Jarvis, Stefano Guerra

Faculty of Medicine

University of Iceland

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Understanding the natural history of abnormal spirometric patterns at different stages of life is critical to identify and optimise preventive strategies. We aimed to describe characteristics and risk factors of restrictive and obstructive spirometric patterns occurring before 40 years (young onset) and between 40 and 61 years (mid-adult onset). Methods: We used data from the population-based cohort of the European Community Respiratory Health Survey (ECRHS). Prebronchodilator forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were assessed longitudinally at baseline (ECRHS1, 1993-1994) and again 20 years later (ECRHS3, 2010-2013). Spirometry patterns were defined as: restrictive if FEV1/FVC≥LLN and FVC<10th percentile, obstructive if FEV1/FVC<LLN or normal otherwise. Five spirometry patterns were derived depending on whether participants never developed restrictive/obstructive (normal), developed restrictive/obstructive at baseline (young onset) or at last follow-up (mid-adult onset). The characteristics and risk factors associated with these patterns were described and assessed using multilevel multinomial logistic regression analysis adjusting for age, sex, sample (random or symptomatic) and centre. Results: Among 3502 participants (mean age=30.4 (SD 5.4) at ECRHS1, 50.4 (SD 5.4) at ECRHS3), 2293 (65%) had a normal, 371 (11%) a young restrictive, 301 (9%) a young obstructive, 187 (5%) a mid-adult onset restrictive and 350 (10%) a mid-adult onset obstructive spirometric pattern. Being lean/underweight in childhood and young adult life was associated with the occurrence of the young spirometric restrictive pattern (relative risk ratio (RRR)=1.61 95% CI=1.21 to 2.14, and RRR=2.43 95% CI=1.80 to 3.29; respectively), so were respiratory infections before 5 years (RRR=1.48, 95% CI=1.05 to 2.08). The main determinants for young obstructive, mid-adult restrictive and mid-adult obstructive patterns were asthma, obesity and smoking, respectively. Conclusion: Spirometric patterns with onset in young and mid-adult life were associated with distinct characteristics and risk factors.

Original language	English
Pages (from-to)	153-162
Number of pages	10
Journal	Thorax
Volume	79
Issue number	2
DOIs	https://doi.org/10.1136/thorax-2022-219696
Publication status	Published - 1 Jan 2024

Bibliographical note

Funding Information: This work was supported by FIS award PS09/01354 from the Instituto de Salud Carlos III. We acknowledge support from the Spanish Ministry of Science and Innovation through the ‘Centro de Excelencia Severo Ochoa 2019-2023’ Programme (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Programme. The funding agencies and principal investigators for the European Community Respiratory Health Survey are reported in the online supplemental appendix 1. The funding source had no role in study design, data collection, data analysis, data interpretation, or writing of the report. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication. Publisher Copyright: © Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.

Other keywords

COPD epidemiology
Clinical Epidemiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1136/thorax-2022-219696

Cite this

Carsin, A. E., Garcia-Aymerich, J., Accordini, S., Dharmage, S., Leynaert, B., De Las Heras, M., Casas, L., Caviezel, S., Demoly, P., Forsberg, B., Gíslason, Þ., Corsico, A. G., Janson, C., Jogi, R., Martínez-Moratalla, J., Nowak, D., Gómez, L. P., Pin, I., Probst-Hensch, N., ... Guerra, S. (2024). Spirometric patterns in young and middle-aged adults: A 20-year European study. Thorax, 79(2), 153-162. https://doi.org/10.1136/thorax-2022-219696

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abstract = "Background: Understanding the natural history of abnormal spirometric patterns at different stages of life is critical to identify and optimise preventive strategies. We aimed to describe characteristics and risk factors of restrictive and obstructive spirometric patterns occurring before 40 years (young onset) and between 40 and 61 years (mid-adult onset). Methods: We used data from the population-based cohort of the European Community Respiratory Health Survey (ECRHS). Prebronchodilator forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were assessed longitudinally at baseline (ECRHS1, 1993-1994) and again 20 years later (ECRHS3, 2010-2013). Spirometry patterns were defined as: restrictive if FEV1/FVC≥LLN and FVC<10th percentile, obstructive if FEV1/FVC",

keywords = "COPD epidemiology, Clinical Epidemiology",

author = "Carsin, \{Anne Elie\} and Judith Garcia-Aymerich and Simone Accordini and Shyamali Dharmage and B{\'e}n{\'e}dicte Leynaert and \{De Las Heras\}, Marti and Lidia Casas and Seraina Caviezel and Pascal Demoly and Bertil Forsberg and {\TH}{\'o}rarinn G{\'i}slason and Corsico, \{Angelo Guido\} and Christer Janson and Rain Jogi and Jes{\'u}s Mart{\'i}nez-Moratalla and Dennis Nowak and G{\'o}mez, \{Leopoldo Palacios\} and Isabelle Pin and Nicole Probst-Hensch and Chantal Raherison-Semjen and Giulia Squillacioti and Cecilie Svanes and Kjell Tor{\'e}n and Isabel Urrutia and Ismael Huerta and Anto, \{Josep Maria\} and Debbie Jarvis and Stefano Guerra",

note = "Funding Information: This work was supported by FIS award PS09/01354 from the Instituto de Salud Carlos III. We acknowledge support from the Spanish Ministry of Science and Innovation through the {\textquoteleft}Centro de Excelencia Severo Ochoa 2019-2023{\textquoteright} Programme (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Programme. The funding agencies and principal investigators for the European Community Respiratory Health Survey are reported in the online supplemental appendix 1. The funding source had no role in study design, data collection, data analysis, data interpretation, or writing of the report. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication. Publisher Copyright: {\textcopyright} Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.",

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doi = "10.1136/thorax-2022-219696",

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Carsin, AE, Garcia-Aymerich, J, Accordini, S, Dharmage, S, Leynaert, B, De Las Heras, M, Casas, L, Caviezel, S, Demoly, P, Forsberg, B, Gíslason, Þ, Corsico, AG, Janson, C, Jogi, R, Martínez-Moratalla, J, Nowak, D, Gómez, LP, Pin, I, Probst-Hensch, N, Raherison-Semjen, C, Squillacioti, G, Svanes, C, Torén, K, Urrutia, I, Huerta, I, Anto, JM, Jarvis, D & Guerra, S 2024, 'Spirometric patterns in young and middle-aged adults: A 20-year European study', Thorax, vol. 79, no. 2, pp. 153-162. https://doi.org/10.1136/thorax-2022-219696

TY - JOUR

T1 - Spirometric patterns in young and middle-aged adults

T2 - A 20-year European study

AU - Carsin, Anne Elie

AU - Garcia-Aymerich, Judith

AU - Accordini, Simone

AU - Dharmage, Shyamali

AU - Leynaert, Bénédicte

AU - De Las Heras, Marti

AU - Casas, Lidia

AU - Caviezel, Seraina

AU - Demoly, Pascal

AU - Forsberg, Bertil

AU - Gíslason, Þórarinn

AU - Corsico, Angelo Guido

AU - Janson, Christer

AU - Jogi, Rain

AU - Martínez-Moratalla, Jesús

AU - Nowak, Dennis

AU - Gómez, Leopoldo Palacios

AU - Pin, Isabelle

AU - Probst-Hensch, Nicole

AU - Raherison-Semjen, Chantal

AU - Squillacioti, Giulia

AU - Svanes, Cecilie

AU - Torén, Kjell

AU - Urrutia, Isabel

AU - Huerta, Ismael

AU - Anto, Josep Maria

AU - Jarvis, Debbie

AU - Guerra, Stefano

N1 - Funding Information: This work was supported by FIS award PS09/01354 from the Instituto de Salud Carlos III. We acknowledge support from the Spanish Ministry of Science and Innovation through the ‘Centro de Excelencia Severo Ochoa 2019-2023’ Programme (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Programme. The funding agencies and principal investigators for the European Community Respiratory Health Survey are reported in the online supplemental appendix 1. The funding source had no role in study design, data collection, data analysis, data interpretation, or writing of the report. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication. Publisher Copyright: © Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2024/1/1

Y1 - 2024/1/1

N2 - Background: Understanding the natural history of abnormal spirometric patterns at different stages of life is critical to identify and optimise preventive strategies. We aimed to describe characteristics and risk factors of restrictive and obstructive spirometric patterns occurring before 40 years (young onset) and between 40 and 61 years (mid-adult onset). Methods: We used data from the population-based cohort of the European Community Respiratory Health Survey (ECRHS). Prebronchodilator forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were assessed longitudinally at baseline (ECRHS1, 1993-1994) and again 20 years later (ECRHS3, 2010-2013). Spirometry patterns were defined as: restrictive if FEV1/FVC≥LLN and FVC<10th percentile, obstructive if FEV1/FVC

AB - Background: Understanding the natural history of abnormal spirometric patterns at different stages of life is critical to identify and optimise preventive strategies. We aimed to describe characteristics and risk factors of restrictive and obstructive spirometric patterns occurring before 40 years (young onset) and between 40 and 61 years (mid-adult onset). Methods: We used data from the population-based cohort of the European Community Respiratory Health Survey (ECRHS). Prebronchodilator forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were assessed longitudinally at baseline (ECRHS1, 1993-1994) and again 20 years later (ECRHS3, 2010-2013). Spirometry patterns were defined as: restrictive if FEV1/FVC≥LLN and FVC<10th percentile, obstructive if FEV1/FVC

KW - COPD epidemiology

KW - Clinical Epidemiology

UR - https://www.scopus.com/pages/publications/85173063186

U2 - 10.1136/thorax-2022-219696

DO - 10.1136/thorax-2022-219696

M3 - Article

SN - 0040-6376

VL - 79

SP - 153

EP - 162

JO - Thorax

JF - Thorax

IS - 2

ER -

Spirometric patterns in young and middle-aged adults: A 20-year European study

Abstract

Bibliographical note

Other keywords

UN SDGs

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Cite this