Studies of curcumin and curcuminoids. XXVII. Cyclodextrin complexation: Solubility, chemical and photochemical stability

Hanne Hjorth Tønnesen; Már Másson; Thorsteinn Loftsson

doi:10.1016/S0378-5173(02)00323-X

Studies of curcumin and curcuminoids. XXVII. Cyclodextrin complexation: Solubility, chemical and photochemical stability

Hanne Hjorth Tønnesen, Már Másson, Thorsteinn Loftsson

Faculty of Pharmaceutical Sciences

University of Iceland

Research output: Contribution to journal › Article › peer-review

Abstract

Cyclodextrin complexes of the natural compound curcumin were prepared in order to improve the water solubility and the hydrolytic and photochemical stability of the compound. Complex formation resulted in an increase in water solubility at pH 5 by a factor of at least 10⁴. The hydrolytic stability of curcumin under alkaline conditions was strongly improved by complex formation, while the photodecomposition rate was increased compared to a curcumin solution in organic solvents. The cavity size and the charge and bulkiness of the cyclodextrin side-chains influenced the stability constant for complexation and the degradation rate of the curcumin molecule.

Original language	English
Pages (from-to)	127-135
Number of pages	9
Journal	International Journal of Pharmaceutics
Volume	244
Issue number	1-2
DOIs	https://doi.org/10.1016/S0378-5173(02)00323-X
Publication status	Published - 5 Sept 2002

Other keywords

Curcumin
Cyclodextrin
Hydrolysis
Photostability
Solubility

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10.1016/S0378-5173(02)00323-X

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title = "Studies of curcumin and curcuminoids. XXVII. Cyclodextrin complexation: Solubility, chemical and photochemical stability",

abstract = "Cyclodextrin complexes of the natural compound curcumin were prepared in order to improve the water solubility and the hydrolytic and photochemical stability of the compound. Complex formation resulted in an increase in water solubility at pH 5 by a factor of at least 104. The hydrolytic stability of curcumin under alkaline conditions was strongly improved by complex formation, while the photodecomposition rate was increased compared to a curcumin solution in organic solvents. The cavity size and the charge and bulkiness of the cyclodextrin side-chains influenced the stability constant for complexation and the degradation rate of the curcumin molecule.",

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T2 - Solubility, chemical and photochemical stability

AU - Tønnesen, Hanne Hjorth

AU - Másson, Már

AU - Loftsson, Thorsteinn

PY - 2002/9/5

Y1 - 2002/9/5

N2 - Cyclodextrin complexes of the natural compound curcumin were prepared in order to improve the water solubility and the hydrolytic and photochemical stability of the compound. Complex formation resulted in an increase in water solubility at pH 5 by a factor of at least 104. The hydrolytic stability of curcumin under alkaline conditions was strongly improved by complex formation, while the photodecomposition rate was increased compared to a curcumin solution in organic solvents. The cavity size and the charge and bulkiness of the cyclodextrin side-chains influenced the stability constant for complexation and the degradation rate of the curcumin molecule.

AB - Cyclodextrin complexes of the natural compound curcumin were prepared in order to improve the water solubility and the hydrolytic and photochemical stability of the compound. Complex formation resulted in an increase in water solubility at pH 5 by a factor of at least 104. The hydrolytic stability of curcumin under alkaline conditions was strongly improved by complex formation, while the photodecomposition rate was increased compared to a curcumin solution in organic solvents. The cavity size and the charge and bulkiness of the cyclodextrin side-chains influenced the stability constant for complexation and the degradation rate of the curcumin molecule.

KW - Curcumin

KW - Cyclodextrin

KW - Hydrolysis

KW - Photostability

KW - Solubility

UR - https://www.scopus.com/pages/publications/0037026270

U2 - 10.1016/S0378-5173(02)00323-X

DO - 10.1016/S0378-5173(02)00323-X

M3 - Article

C2 - 12204572

SN - 0378-5173

VL - 244

SP - 127

EP - 135

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

IS - 1-2

ER -

Studies of curcumin and curcuminoids. XXVII. Cyclodextrin complexation: Solubility, chemical and photochemical stability

Abstract

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