Systems biology as a foundation for genome-scale synthetic biology

Christian L. Barrett; Tae Yong Kim; Hyun Uk Kim; Bernhard Palsson; Sang Yup Lee

doi:10.1016/j.copbio.2006.08.001

Systems biology as a foundation for genome-scale synthetic biology

Christian L. Barrett, Tae Yong Kim, Hyun Uk Kim, Bernhard Palsson, Sang Yup Lee

University of Iceland

University of Iceland

Research output: Contribution to journal › Review article › peer-review

Abstract

As the ambitions of synthetic biology approach genome-scale engineering, comprehensive characterization of cellular systems is required, as well as a means to accurately model cell-scale molecular interactions. These requirements are coincident with the goals of systems biology and, thus, systems biology will become the foundation for genome-scale synthetic biology. Systems biology will form this foundation through its efforts to reconstruct and integrate cellular systems, develop the mathematics, theory and software tools for the accurate modeling of these integrated systems, and through evolutionary mechanisms. As genome-scale synthetic biology is so enabled, it will prove to be a positive feedback driver of systems biology by exposing and forcing researchers to confront those aspects of systems biology which are inadequately understood.

Original language	English
Pages (from-to)	488-492
Number of pages	5
Journal	Current Opinion in Biotechnology
Volume	17
Issue number	5
DOIs	https://doi.org/10.1016/j.copbio.2006.08.001
Publication status	Published - Oct 2006

Bibliographical note

Funding Information: The work of SYL was supported by the Korean Systems Biology Research Project (M10309020000–03B5002–00000) of the Ministry of Science and Technology, the BK21 Project, and by the LG Chem Chair Professorship.

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title = "Systems biology as a foundation for genome-scale synthetic biology",

abstract = "As the ambitions of synthetic biology approach genome-scale engineering, comprehensive characterization of cellular systems is required, as well as a means to accurately model cell-scale molecular interactions. These requirements are coincident with the goals of systems biology and, thus, systems biology will become the foundation for genome-scale synthetic biology. Systems biology will form this foundation through its efforts to reconstruct and integrate cellular systems, develop the mathematics, theory and software tools for the accurate modeling of these integrated systems, and through evolutionary mechanisms. As genome-scale synthetic biology is so enabled, it will prove to be a positive feedback driver of systems biology by exposing and forcing researchers to confront those aspects of systems biology which are inadequately understood.",

author = "Barrett, \{Christian L.\} and Kim, \{Tae Yong\} and Kim, \{Hyun Uk\} and Bernhard Palsson and Lee, \{Sang Yup\}",

note = "Funding Information: The work of SYL was supported by the Korean Systems Biology Research Project (M10309020000–03B5002–00000) of the Ministry of Science and Technology, the BK21 Project, and by the LG Chem Chair Professorship.",

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doi = "10.1016/j.copbio.2006.08.001",

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AU - Barrett, Christian L.

AU - Kim, Tae Yong

AU - Kim, Hyun Uk

AU - Palsson, Bernhard

AU - Lee, Sang Yup

N1 - Funding Information: The work of SYL was supported by the Korean Systems Biology Research Project (M10309020000–03B5002–00000) of the Ministry of Science and Technology, the BK21 Project, and by the LG Chem Chair Professorship.

PY - 2006/10

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N2 - As the ambitions of synthetic biology approach genome-scale engineering, comprehensive characterization of cellular systems is required, as well as a means to accurately model cell-scale molecular interactions. These requirements are coincident with the goals of systems biology and, thus, systems biology will become the foundation for genome-scale synthetic biology. Systems biology will form this foundation through its efforts to reconstruct and integrate cellular systems, develop the mathematics, theory and software tools for the accurate modeling of these integrated systems, and through evolutionary mechanisms. As genome-scale synthetic biology is so enabled, it will prove to be a positive feedback driver of systems biology by exposing and forcing researchers to confront those aspects of systems biology which are inadequately understood.

AB - As the ambitions of synthetic biology approach genome-scale engineering, comprehensive characterization of cellular systems is required, as well as a means to accurately model cell-scale molecular interactions. These requirements are coincident with the goals of systems biology and, thus, systems biology will become the foundation for genome-scale synthetic biology. Systems biology will form this foundation through its efforts to reconstruct and integrate cellular systems, develop the mathematics, theory and software tools for the accurate modeling of these integrated systems, and through evolutionary mechanisms. As genome-scale synthetic biology is so enabled, it will prove to be a positive feedback driver of systems biology by exposing and forcing researchers to confront those aspects of systems biology which are inadequately understood.

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U2 - 10.1016/j.copbio.2006.08.001

DO - 10.1016/j.copbio.2006.08.001

M3 - Review article

C2 - 16934450

SN - 0958-1669

VL - 17

SP - 488

EP - 492

JO - Current Opinion in Biotechnology

JF - Current Opinion in Biotechnology

IS - 5

ER -

Systems biology as a foundation for genome-scale synthetic biology

Abstract

Bibliographical note

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