Abstract
A complex nervous system comprises two distinct cell types, neurons and glial cells, whose development, differentiation and function is mutually interdependent. Many studies contributed to uncovering the basic mechanisms determining neuronal and glial fate and we are progressing enormously towards an understanding of how neurons interconnect to form intricate neuronal networks. However, the mechanisms used to couple neuronal and glial development remain largely obscure. Here we advocate the usefulness of the developing Drosophila compound eye as a new model to study the complex relationship between glial and neuronal cells.
| Original language | English |
|---|---|
| Pages (from-to) | 71-79 |
| Number of pages | 9 |
| Journal | Fly |
| Volume | 4 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2010 |
Bibliographical note
Funding Information: We thank T. Hummel and an anonymous reviewer for comments on the manuscript and members of the Klämbt lab for continuous support and discussions. This work was supported through a PhD fellowship of the Boehringer Ingelheim Foundation to M.S. and grants of the Deutsche Forschungsgemeinschaft (SFB629) and funds from the European Community’s Seventh Framework Programme (FP7/2007-2013) under grant agreement No. HEALTH-F2-2008-201535 to Christian Klämbt.Other keywords
- Development
- Drosophila
- FGF signaling
- Neuron-glia interaction