Time Trends of Acrylamide Exposure in Europe: Combined Analysis of Published Reports and Current HBM4EU Studies

Michael Poteser; Federica Laguzzi; Thomas Schettgen; Nina Vogel; Till Weber; Philipp Zimmermann; Domenica Hahn; Marike Kolossa-Gehring; Sónia Namorado; An Van Nieuwenhuyse; Brice Appenzeller; Thórhallur I. Halldórsson; Ása Eiríksdóttir; Line Småstuen Haug; Cathrine Thomsen; Fabio Barbone; Valentina Rosolen; Loïc Rambaud; Margaux Riou; Thomas Göen; Stefanie Nübler; Moritz Schäfer; Karin Haji Abbas Zarrabi; Liese Gilles; Laura Rodriguez Martin; Greet Schoeters; Ovnair Sepai; Eva Govarts; Hanns Moshammer

doi:10.3390/toxics10080481

Time Trends of Acrylamide Exposure in Europe: Combined Analysis of Published Reports and Current HBM4EU Studies

Michael Poteser, Federica Laguzzi, Thomas Schettgen, Nina Vogel, Till Weber, Philipp Zimmermann, Domenica Hahn, Marike Kolossa-Gehring, Sónia Namorado, An Van Nieuwenhuyse, Brice Appenzeller, Thórhallur I. Halldórsson, Ása Eiríksdóttir, Line Småstuen Haug, Cathrine Thomsen, Fabio Barbone, Valentina Rosolen, Loïc Rambaud, Margaux Riou, Thomas GöenStefanie Nübler, Moritz Schäfer, Karin Haji Abbas Zarrabi, Liese Gilles, Laura Rodriguez Martin, Greet Schoeters, Ovnair Sepai, Eva Govarts, Hanns Moshammer

University of Iceland

University of Iceland

Research output: Contribution to journal › Article › peer-review

Abstract

More than 20 years ago, acrylamide was added to the list of potential carcinogens found in many common dietary products and tobacco smoke. Consequently, human biomonitoring studies investigating exposure to acrylamide in the form of adducts in blood and metabolites in urine have been performed to obtain data on the actual burden in different populations of the world and in Europe. Recognizing the related health risk, the European Commission responded with measures to curb the acrylamide content in food products. In 2017, a trans-European human biomonitoring project (HBM4EU) was started with the aim to investigate exposure to several chemicals, including acrylamide. Here we set out to provide a combined analysis of previous and current European acrylamide biomonitoring study results by harmonizing and integrating different data sources, including HBM4EU aligned studies, with the aim to resolve overall and current time trends of acrylamide exposure in Europe. Data from 10 European countries were included in the analysis, comprising more than 5500 individual samples (3214 children and teenagers, 2293 adults). We utilized linear models as well as a non-linear fit and breakpoint analysis to investigate trends in temporal acrylamide exposure as well as descriptive statistics and statistical tests to validate findings. Our results indicate an overall increase in acrylamide exposure between the years 2001 and 2017. Studies with samples collected after 2018 focusing on adults do not indicate increasing exposure but show declining values. Regional differences appear to affect absolute values, but not the overall time-trend of exposure. As benchmark levels for acrylamide content in food have been adopted in Europe in 2018, our results may imply the effects of these measures, but only indicated for adults, as corresponding data are still missing for children.

Original language	English
Article number	481
Journal	Toxics
Volume	10
Issue number	8
DOIs	https://doi.org/10.3390/toxics10080481
Publication status	Published - 17 Aug 2022

Bibliographical note

Funding Information: The authors acknowledge all the participating and expert laboratories involved, including the HBM4EU QA/QC program, the Management and Advisory Boards of HBM4EU, and the funding received from the European Union’s Horizon 2020 research and innovation program (grant agreement No. 733032). Funding Information: This work has received external funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 733032 and received co-funding from the author’s organizations. The Norwegian Institute of Public Health (NIPH) has contributed to the funding of the Norwegian Environmental Biobank (NEB). The Norwegian Environmental Biobank is a substudy within MoBa established with the aim of biomonitoring nutrients and environmental contaminants in mothers, fathers, and children participating in MoBa. The study included approximately six hundred triads of mothers, fathers, and children who donated blood and urine samples, and responded to a questionnaire. The laboratory measurements have partly been funded by the Research Council of Norway through research projects (275903 and 268465). Publisher Copyright: © 2022 by the authors.

Other keywords

HBM
acrylamide
exposure level
glycidamide
human biomonitoring
time-trend

Access to Document

10.3390/toxics10080481

Cite this

Poteser, M., Laguzzi, F., Schettgen, T., Vogel, N., Weber, T., Zimmermann, P., Hahn, D., Kolossa-Gehring, M., Namorado, S., Van Nieuwenhuyse, A., Appenzeller, B., Halldórsson, T. I., Eiríksdóttir, Á., Haug, L. S., Thomsen, C., Barbone, F., Rosolen, V., Rambaud, L., Riou, M., ... Moshammer, H. (2022). Time Trends of Acrylamide Exposure in Europe: Combined Analysis of Published Reports and Current HBM4EU Studies. Toxics, 10(8), Article 481. https://doi.org/10.3390/toxics10080481

@article{7a6ec9c4522b407ab3d4876cfc76ee0b,

title = "Time Trends of Acrylamide Exposure in Europe: Combined Analysis of Published Reports and Current HBM4EU Studies",

abstract = "More than 20 years ago, acrylamide was added to the list of potential carcinogens found in many common dietary products and tobacco smoke. Consequently, human biomonitoring studies investigating exposure to acrylamide in the form of adducts in blood and metabolites in urine have been performed to obtain data on the actual burden in different populations of the world and in Europe. Recognizing the related health risk, the European Commission responded with measures to curb the acrylamide content in food products. In 2017, a trans-European human biomonitoring project (HBM4EU) was started with the aim to investigate exposure to several chemicals, including acrylamide. Here we set out to provide a combined analysis of previous and current European acrylamide biomonitoring study results by harmonizing and integrating different data sources, including HBM4EU aligned studies, with the aim to resolve overall and current time trends of acrylamide exposure in Europe. Data from 10 European countries were included in the analysis, comprising more than 5500 individual samples (3214 children and teenagers, 2293 adults). We utilized linear models as well as a non-linear fit and breakpoint analysis to investigate trends in temporal acrylamide exposure as well as descriptive statistics and statistical tests to validate findings. Our results indicate an overall increase in acrylamide exposure between the years 2001 and 2017. Studies with samples collected after 2018 focusing on adults do not indicate increasing exposure but show declining values. Regional differences appear to affect absolute values, but not the overall time-trend of exposure. As benchmark levels for acrylamide content in food have been adopted in Europe in 2018, our results may imply the effects of these measures, but only indicated for adults, as corresponding data are still missing for children.",

keywords = "HBM, acrylamide, exposure level, glycidamide, human biomonitoring, time-trend",

author = "Michael Poteser and Federica Laguzzi and Thomas Schettgen and Nina Vogel and Till Weber and Philipp Zimmermann and Domenica Hahn and Marike Kolossa-Gehring and S{\'o}nia Namorado and \{Van Nieuwenhuyse\}, An and Brice Appenzeller and Halld{\'o}rsson, \{Th{\'o}rhallur I.\} and {\'A}sa Eir{\'i}ksd{\'o}ttir and Haug, \{Line Sm{\aa}stuen\} and Cathrine Thomsen and Fabio Barbone and Valentina Rosolen and Lo{\"i}c Rambaud and Margaux Riou and Thomas G{\"o}en and Stefanie N{\"u}bler and Moritz Sch{\"a}fer and \{Haji Abbas Zarrabi\}, Karin and Liese Gilles and Martin, \{Laura Rodriguez\} and Greet Schoeters and Ovnair Sepai and Eva Govarts and Hanns Moshammer",

note = "Funding Information: The authors acknowledge all the participating and expert laboratories involved, including the HBM4EU QA/QC program, the Management and Advisory Boards of HBM4EU, and the funding received from the European Union{\textquoteright}s Horizon 2020 research and innovation program (grant agreement No. 733032). Funding Information: This work has received external funding from the European Union{\textquoteright}s Horizon 2020 research and innovation program under grant agreement No. 733032 and received co-funding from the author{\textquoteright}s organizations. The Norwegian Institute of Public Health (NIPH) has contributed to the funding of the Norwegian Environmental Biobank (NEB). The Norwegian Environmental Biobank is a substudy within MoBa established with the aim of biomonitoring nutrients and environmental contaminants in mothers, fathers, and children participating in MoBa. The study included approximately six hundred triads of mothers, fathers, and children who donated blood and urine samples, and responded to a questionnaire. The laboratory measurements have partly been funded by the Research Council of Norway through research projects (275903 and 268465). Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = aug,

day = "17",

doi = "10.3390/toxics10080481",

language = "English",

volume = "10",

journal = "Toxics",

issn = "2305-6304",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "8",

}

Poteser, M, Laguzzi, F, Schettgen, T, Vogel, N, Weber, T, Zimmermann, P, Hahn, D, Kolossa-Gehring, M, Namorado, S, Van Nieuwenhuyse, A, Appenzeller, B, Halldórsson, TI, Eiríksdóttir, Á, Haug, LS, Thomsen, C, Barbone, F, Rosolen, V, Rambaud, L, Riou, M, Göen, T, Nübler, S, Schäfer, M, Haji Abbas Zarrabi, K, Gilles, L, Martin, LR, Schoeters, G, Sepai, O, Govarts, E & Moshammer, H 2022, 'Time Trends of Acrylamide Exposure in Europe: Combined Analysis of Published Reports and Current HBM4EU Studies', Toxics, vol. 10, no. 8, 481. https://doi.org/10.3390/toxics10080481

TY - JOUR

T1 - Time Trends of Acrylamide Exposure in Europe

T2 - Combined Analysis of Published Reports and Current HBM4EU Studies

AU - Poteser, Michael

AU - Laguzzi, Federica

AU - Schettgen, Thomas

AU - Vogel, Nina

AU - Weber, Till

AU - Zimmermann, Philipp

AU - Hahn, Domenica

AU - Kolossa-Gehring, Marike

AU - Namorado, Sónia

AU - Van Nieuwenhuyse, An

AU - Appenzeller, Brice

AU - Halldórsson, Thórhallur I.

AU - Eiríksdóttir, Ása

AU - Haug, Line Småstuen

AU - Thomsen, Cathrine

AU - Barbone, Fabio

AU - Rosolen, Valentina

AU - Rambaud, Loïc

AU - Riou, Margaux

AU - Göen, Thomas

AU - Nübler, Stefanie

AU - Schäfer, Moritz

AU - Haji Abbas Zarrabi, Karin

AU - Gilles, Liese

AU - Martin, Laura Rodriguez

AU - Schoeters, Greet

AU - Sepai, Ovnair

AU - Govarts, Eva

AU - Moshammer, Hanns

N1 - Funding Information: The authors acknowledge all the participating and expert laboratories involved, including the HBM4EU QA/QC program, the Management and Advisory Boards of HBM4EU, and the funding received from the European Union’s Horizon 2020 research and innovation program (grant agreement No. 733032). Funding Information: This work has received external funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 733032 and received co-funding from the author’s organizations. The Norwegian Institute of Public Health (NIPH) has contributed to the funding of the Norwegian Environmental Biobank (NEB). The Norwegian Environmental Biobank is a substudy within MoBa established with the aim of biomonitoring nutrients and environmental contaminants in mothers, fathers, and children participating in MoBa. The study included approximately six hundred triads of mothers, fathers, and children who donated blood and urine samples, and responded to a questionnaire. The laboratory measurements have partly been funded by the Research Council of Norway through research projects (275903 and 268465). Publisher Copyright: © 2022 by the authors.

PY - 2022/8/17

Y1 - 2022/8/17

N2 - More than 20 years ago, acrylamide was added to the list of potential carcinogens found in many common dietary products and tobacco smoke. Consequently, human biomonitoring studies investigating exposure to acrylamide in the form of adducts in blood and metabolites in urine have been performed to obtain data on the actual burden in different populations of the world and in Europe. Recognizing the related health risk, the European Commission responded with measures to curb the acrylamide content in food products. In 2017, a trans-European human biomonitoring project (HBM4EU) was started with the aim to investigate exposure to several chemicals, including acrylamide. Here we set out to provide a combined analysis of previous and current European acrylamide biomonitoring study results by harmonizing and integrating different data sources, including HBM4EU aligned studies, with the aim to resolve overall and current time trends of acrylamide exposure in Europe. Data from 10 European countries were included in the analysis, comprising more than 5500 individual samples (3214 children and teenagers, 2293 adults). We utilized linear models as well as a non-linear fit and breakpoint analysis to investigate trends in temporal acrylamide exposure as well as descriptive statistics and statistical tests to validate findings. Our results indicate an overall increase in acrylamide exposure between the years 2001 and 2017. Studies with samples collected after 2018 focusing on adults do not indicate increasing exposure but show declining values. Regional differences appear to affect absolute values, but not the overall time-trend of exposure. As benchmark levels for acrylamide content in food have been adopted in Europe in 2018, our results may imply the effects of these measures, but only indicated for adults, as corresponding data are still missing for children.

AB - More than 20 years ago, acrylamide was added to the list of potential carcinogens found in many common dietary products and tobacco smoke. Consequently, human biomonitoring studies investigating exposure to acrylamide in the form of adducts in blood and metabolites in urine have been performed to obtain data on the actual burden in different populations of the world and in Europe. Recognizing the related health risk, the European Commission responded with measures to curb the acrylamide content in food products. In 2017, a trans-European human biomonitoring project (HBM4EU) was started with the aim to investigate exposure to several chemicals, including acrylamide. Here we set out to provide a combined analysis of previous and current European acrylamide biomonitoring study results by harmonizing and integrating different data sources, including HBM4EU aligned studies, with the aim to resolve overall and current time trends of acrylamide exposure in Europe. Data from 10 European countries were included in the analysis, comprising more than 5500 individual samples (3214 children and teenagers, 2293 adults). We utilized linear models as well as a non-linear fit and breakpoint analysis to investigate trends in temporal acrylamide exposure as well as descriptive statistics and statistical tests to validate findings. Our results indicate an overall increase in acrylamide exposure between the years 2001 and 2017. Studies with samples collected after 2018 focusing on adults do not indicate increasing exposure but show declining values. Regional differences appear to affect absolute values, but not the overall time-trend of exposure. As benchmark levels for acrylamide content in food have been adopted in Europe in 2018, our results may imply the effects of these measures, but only indicated for adults, as corresponding data are still missing for children.

KW - HBM

KW - acrylamide

KW - exposure level

KW - glycidamide

KW - human biomonitoring

KW - time-trend

UR - https://www.scopus.com/pages/publications/85137325638

U2 - 10.3390/toxics10080481

DO - 10.3390/toxics10080481

M3 - Article

C2 - 36006160

SN - 2305-6304

VL - 10

JO - Toxics

JF - Toxics

IS - 8

M1 - 481

ER -

Time Trends of Acrylamide Exposure in Europe: Combined Analysis of Published Reports and Current HBM4EU Studies

Abstract

Bibliographical note

Other keywords

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Cite this