White matter hyperintensity shape is associated with long-term dementia risk

Jasmin Annica Keller; Sigurdur Sigurdsson; Kelly Klaassen; Lydiane Hirschler; Mark A. van Buchem; Lenore J. Launer; Matthias J.P. van Osch; Vilmundur Gudnason; Jeroen H.J.M. de Bresser

doi:10.1002/alz.13345

White matter hyperintensity shape is associated with long-term dementia risk

Jasmin Annica Keller
, Sigurdur Sigurdsson
, Kelly Klaassen
, Lydiane Hirschler
, Mark A. van Buchem
, Lenore J. Launer
, Matthias J.P. van Osch
, Vilmundur Gudnason
, Jeroen H.J.M. de Bresser

Faculty of Medicine

University of Iceland

Research output: Contribution to journal › Article › peer-review

Abstract

INTRODUCTION: We aimed to investigate the association between white matter hyperintensity (WMH) shape and volume and the long-term dementia risk in community-dwelling older adults.

METHODS: Three thousand seventy-seven participants (mean age: 75.6 ± 5.2 years) of the Age Gene/Environment Susceptibility (AGES)-Reykjavik study underwent baseline 1.5T brain magnetic resonance imaging and were followed up for dementia (mean follow-up: 9.9 ± 2.6 years).

RESULTS: More irregular shape of periventricular/confluent WMH (lower solidity (hazard ratio (95% confidence interval) 1.34 (1.17 to 1.52), p < .001) and convexity 1.38 (1.28 to 1.49), p < .001); higher concavity index 1.43 (1.32 to 1.54), p < .001) and fractal dimension 1.45 (1.32 to 1.58), p < .001)), higher total WMH volume (1.68 (1.54 to 1.87), p < .001), higher periventricular/confluent WMH volume (1.71 (1.55 to 1.89), p < .001), and higher deep WMH volume (1.17 (1.08 to 1.27), p < .001) were associated with an increased long-term dementia risk.

DISCUSSION: WMH shape markers may in the future be useful in determining patient prognosis and may aid in patient selection for future preventive treatments in community-dwelling older adults.

Original language	English
Pages (from-to)	5632-5641
Number of pages	10
Journal	Alzheimer's and Dementia
Volume	19
Issue number	12
DOIs	https://doi.org/10.1002/alz.13345
Publication status	Published - Dec 2023

Bibliographical note

Funding Information: The authors want to thank Myriam Jaarsma‐Coes for her help with the software. The Age, Gene/Environment Susceptibility‐Reykjavik Study was supported by NIH contracts N01‐AG‐1‐2100 and HHSN27120120022C, the NIA Intramural Research Program, Hjartavernd (Icelandic Heart Association), and Althingi (Icelandic Parliament). This work was supported by an Alzheimer's Nederland grant (WE.03‐2019‐08) to Jeroen de Bresser. Publisher Copyright: © 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

Other keywords

cerebral small vessel disease
cognitive decline
dementia
magnetic resonance imaging
white matter hyperintensities

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10.1002/alz.13345

Cite this

@article{a14e47b4915f4bd2b2e6556f0b5d1018,

title = "White matter hyperintensity shape is associated with long-term dementia risk",

abstract = "INTRODUCTION: We aimed to investigate the association between white matter hyperintensity (WMH) shape and volume and the long-term dementia risk in community-dwelling older adults.METHODS: Three thousand seventy-seven participants (mean age: 75.6 ± 5.2 years) of the Age Gene/Environment Susceptibility (AGES)-Reykjavik study underwent baseline 1.5T brain magnetic resonance imaging and were followed up for dementia (mean follow-up: 9.9 ± 2.6 years).RESULTS: More irregular shape of periventricular/confluent WMH (lower solidity (hazard ratio (95\% confidence interval) 1.34 (1.17 to 1.52), p < .001) and convexity 1.38 (1.28 to 1.49), p < .001); higher concavity index 1.43 (1.32 to 1.54), p < .001) and fractal dimension 1.45 (1.32 to 1.58), p < .001)), higher total WMH volume (1.68 (1.54 to 1.87), p < .001), higher periventricular/confluent WMH volume (1.71 (1.55 to 1.89), p < .001), and higher deep WMH volume (1.17 (1.08 to 1.27), p < .001) were associated with an increased long-term dementia risk.DISCUSSION: WMH shape markers may in the future be useful in determining patient prognosis and may aid in patient selection for future preventive treatments in community-dwelling older adults.",

keywords = "cerebral small vessel disease, cognitive decline, dementia, magnetic resonance imaging, white matter hyperintensities",

author = "Keller, \{Jasmin Annica\} and Sigurdur Sigurdsson and Kelly Klaassen and Lydiane Hirschler and \{van Buchem\}, \{Mark A.\} and Launer, \{Lenore J.\} and \{van Osch\}, \{Matthias J.P.\} and Vilmundur Gudnason and \{de Bresser\}, \{Jeroen H.J.M.\}",

note = "Funding Information: The authors want to thank Myriam Jaarsma‐Coes for her help with the software. The Age, Gene/Environment Susceptibility‐Reykjavik Study was supported by NIH contracts N01‐AG‐1‐2100 and HHSN27120120022C, the NIA Intramural Research Program, Hjartavernd (Icelandic Heart Association), and Althingi (Icelandic Parliament). This work was supported by an Alzheimer's Nederland grant (WE.03‐2019‐08) to Jeroen de Bresser. Publisher Copyright: {\textcopyright} 2023 The Authors. Alzheimer's \& Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.",

year = "2023",

month = dec,

doi = "10.1002/alz.13345",

language = "English",

volume = "19",

pages = "5632--5641",

journal = "Alzheimer's and Dementia",

issn = "1552-5260",

publisher = "John Wiley and Sons Inc.",

number = "12",

}

TY - JOUR

T1 - White matter hyperintensity shape is associated with long-term dementia risk

AU - Keller, Jasmin Annica

AU - Sigurdsson, Sigurdur

AU - Klaassen, Kelly

AU - Hirschler, Lydiane

AU - van Buchem, Mark A.

AU - Launer, Lenore J.

AU - van Osch, Matthias J.P.

AU - Gudnason, Vilmundur

AU - de Bresser, Jeroen H.J.M.

N1 - Funding Information: The authors want to thank Myriam Jaarsma‐Coes for her help with the software. The Age, Gene/Environment Susceptibility‐Reykjavik Study was supported by NIH contracts N01‐AG‐1‐2100 and HHSN27120120022C, the NIA Intramural Research Program, Hjartavernd (Icelandic Heart Association), and Althingi (Icelandic Parliament). This work was supported by an Alzheimer's Nederland grant (WE.03‐2019‐08) to Jeroen de Bresser. Publisher Copyright: © 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

PY - 2023/12

Y1 - 2023/12

N2 - INTRODUCTION: We aimed to investigate the association between white matter hyperintensity (WMH) shape and volume and the long-term dementia risk in community-dwelling older adults.METHODS: Three thousand seventy-seven participants (mean age: 75.6 ± 5.2 years) of the Age Gene/Environment Susceptibility (AGES)-Reykjavik study underwent baseline 1.5T brain magnetic resonance imaging and were followed up for dementia (mean follow-up: 9.9 ± 2.6 years).RESULTS: More irregular shape of periventricular/confluent WMH (lower solidity (hazard ratio (95% confidence interval) 1.34 (1.17 to 1.52), p < .001) and convexity 1.38 (1.28 to 1.49), p < .001); higher concavity index 1.43 (1.32 to 1.54), p < .001) and fractal dimension 1.45 (1.32 to 1.58), p < .001)), higher total WMH volume (1.68 (1.54 to 1.87), p < .001), higher periventricular/confluent WMH volume (1.71 (1.55 to 1.89), p < .001), and higher deep WMH volume (1.17 (1.08 to 1.27), p < .001) were associated with an increased long-term dementia risk.DISCUSSION: WMH shape markers may in the future be useful in determining patient prognosis and may aid in patient selection for future preventive treatments in community-dwelling older adults.

AB - INTRODUCTION: We aimed to investigate the association between white matter hyperintensity (WMH) shape and volume and the long-term dementia risk in community-dwelling older adults.METHODS: Three thousand seventy-seven participants (mean age: 75.6 ± 5.2 years) of the Age Gene/Environment Susceptibility (AGES)-Reykjavik study underwent baseline 1.5T brain magnetic resonance imaging and were followed up for dementia (mean follow-up: 9.9 ± 2.6 years).RESULTS: More irregular shape of periventricular/confluent WMH (lower solidity (hazard ratio (95% confidence interval) 1.34 (1.17 to 1.52), p < .001) and convexity 1.38 (1.28 to 1.49), p < .001); higher concavity index 1.43 (1.32 to 1.54), p < .001) and fractal dimension 1.45 (1.32 to 1.58), p < .001)), higher total WMH volume (1.68 (1.54 to 1.87), p < .001), higher periventricular/confluent WMH volume (1.71 (1.55 to 1.89), p < .001), and higher deep WMH volume (1.17 (1.08 to 1.27), p < .001) were associated with an increased long-term dementia risk.DISCUSSION: WMH shape markers may in the future be useful in determining patient prognosis and may aid in patient selection for future preventive treatments in community-dwelling older adults.

KW - cerebral small vessel disease

KW - cognitive decline

KW - dementia

KW - magnetic resonance imaging

KW - white matter hyperintensities

UR - https://www.scopus.com/pages/publications/85161668561

U2 - 10.1002/alz.13345

DO - 10.1002/alz.13345

M3 - Article

C2 - 37303267

SN - 1552-5260

VL - 19

SP - 5632

EP - 5641

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - 12

ER -

White matter hyperintensity shape is associated with long-term dementia risk

Abstract

Bibliographical note

Other keywords

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