Heightened cortisol responses to daily stress in working women at familial risk for breast cancer

Lucia Dettenborn; Gary D. James; Helene Van Berge-Landry; Heiddis B. Valdimarsdottir; Guy H. Montgomery; Dana H. Bovbjerg

doi:10.1016/j.biopsycho.2004.07.004

Heightened cortisol responses to daily stress in working women at familial risk for breast cancer

Lucia Dettenborn
, Gary D. James
, Helene Van Berge-Landry
, Heiddis B. Valdimarsdottir
, Guy H. Montgomery
, Dana H. Bovbjerg

Sálfræðideild

Háskólinn í Reykjavík

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Útdráttur

Consistent with animal models and experimental studies with humans facing other 'background' stressors, women at familial risk for breast cancer have been reported to have stronger cortisol responses to laboratory stressors. To explore the relevance of these findings to daily life, we compared work-stress cortisol responses in women with ≥1 first-degree relative with breast cancer (FH+, n = 74) to women without this risk factor (FH-, n = 141). Repeated-measures ANOVA revealed a group by time interaction (p ≤ 0.05) with FH+ women having higher (p ≤ 0.05) urinary cortisol levels than FH- during work, but not at home or during sleep. They also had a higher percentage increase between nadir cortisol levels and work levels. These results provide evidence that the heightened cortisol responses of FH+ women also apply to daily life stressors, and suggest the need for additional research to explore the possibility that accentuated hypothalamic-pituitary-axis responses to such stressors may increase health risk for these women.

Upprunalegt tungumál	Enska
Síður (frá-til)	167-179
Síðufjöldi	13
Fræðitímarit	Biological Psychology
Bindi	69
Númer tölublaðs	2
DOI	https://doi.org/10.1016/j.biopsycho.2004.07.004
Útgáfustaða	Útgefið - maí 2005

Athugasemd

Funding Information: This work was supported by grants from the National Cancer Institute (Bovbjerg, CA72457) and the Army (Bovbjerg, DAMD17-99-1-9303; Dettenborn, DAMD 17-03-1-0346). The authors would like to thank Dr. Dirk Hellhammer and Dr. Stefan Gold, as well as the Associate Editor and anonymous reviewers for their comments on an earlier version of the manuscript, and the research participants for their invaluable contribution of time and effort to the study.

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10.1016/j.biopsycho.2004.07.004

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@article{ee4f5034dcb649d3b8334df5d9570291,

title = "Heightened cortisol responses to daily stress in working women at familial risk for breast cancer",

abstract = "Consistent with animal models and experimental studies with humans facing other 'background' stressors, women at familial risk for breast cancer have been reported to have stronger cortisol responses to laboratory stressors. To explore the relevance of these findings to daily life, we compared work-stress cortisol responses in women with ≥1 first-degree relative with breast cancer (FH+, n = 74) to women without this risk factor (FH-, n = 141). Repeated-measures ANOVA revealed a group by time interaction (p ≤ 0.05) with FH+ women having higher (p ≤ 0.05) urinary cortisol levels than FH- during work, but not at home or during sleep. They also had a higher percentage increase between nadir cortisol levels and work levels. These results provide evidence that the heightened cortisol responses of FH+ women also apply to daily life stressors, and suggest the need for additional research to explore the possibility that accentuated hypothalamic-pituitary-axis responses to such stressors may increase health risk for these women.",

keywords = "Breast cancer, Cortisol, Familial risk, Work stress",

author = "Lucia Dettenborn and James, \{Gary D.\} and \{Van Berge-Landry\}, Helene and Valdimarsdottir, \{Heiddis B.\} and Montgomery, \{Guy H.\} and Bovbjerg, \{Dana H.\}",

note = "Funding Information: This work was supported by grants from the National Cancer Institute (Bovbjerg, CA72457) and the Army (Bovbjerg, DAMD17-99-1-9303; Dettenborn, DAMD 17-03-1-0346). The authors would like to thank Dr. Dirk Hellhammer and Dr. Stefan Gold, as well as the Associate Editor and anonymous reviewers for their comments on an earlier version of the manuscript, and the research participants for their invaluable contribution of time and effort to the study.",

year = "2005",

month = may,

doi = "10.1016/j.biopsycho.2004.07.004",

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TY - JOUR

T1 - Heightened cortisol responses to daily stress in working women at familial risk for breast cancer

AU - Dettenborn, Lucia

AU - James, Gary D.

AU - Van Berge-Landry, Helene

AU - Valdimarsdottir, Heiddis B.

AU - Montgomery, Guy H.

AU - Bovbjerg, Dana H.

N1 - Funding Information: This work was supported by grants from the National Cancer Institute (Bovbjerg, CA72457) and the Army (Bovbjerg, DAMD17-99-1-9303; Dettenborn, DAMD 17-03-1-0346). The authors would like to thank Dr. Dirk Hellhammer and Dr. Stefan Gold, as well as the Associate Editor and anonymous reviewers for their comments on an earlier version of the manuscript, and the research participants for their invaluable contribution of time and effort to the study.

PY - 2005/5

Y1 - 2005/5

N2 - Consistent with animal models and experimental studies with humans facing other 'background' stressors, women at familial risk for breast cancer have been reported to have stronger cortisol responses to laboratory stressors. To explore the relevance of these findings to daily life, we compared work-stress cortisol responses in women with ≥1 first-degree relative with breast cancer (FH+, n = 74) to women without this risk factor (FH-, n = 141). Repeated-measures ANOVA revealed a group by time interaction (p ≤ 0.05) with FH+ women having higher (p ≤ 0.05) urinary cortisol levels than FH- during work, but not at home or during sleep. They also had a higher percentage increase between nadir cortisol levels and work levels. These results provide evidence that the heightened cortisol responses of FH+ women also apply to daily life stressors, and suggest the need for additional research to explore the possibility that accentuated hypothalamic-pituitary-axis responses to such stressors may increase health risk for these women.

AB - Consistent with animal models and experimental studies with humans facing other 'background' stressors, women at familial risk for breast cancer have been reported to have stronger cortisol responses to laboratory stressors. To explore the relevance of these findings to daily life, we compared work-stress cortisol responses in women with ≥1 first-degree relative with breast cancer (FH+, n = 74) to women without this risk factor (FH-, n = 141). Repeated-measures ANOVA revealed a group by time interaction (p ≤ 0.05) with FH+ women having higher (p ≤ 0.05) urinary cortisol levels than FH- during work, but not at home or during sleep. They also had a higher percentage increase between nadir cortisol levels and work levels. These results provide evidence that the heightened cortisol responses of FH+ women also apply to daily life stressors, and suggest the need for additional research to explore the possibility that accentuated hypothalamic-pituitary-axis responses to such stressors may increase health risk for these women.

KW - Breast cancer

KW - Cortisol

KW - Familial risk

KW - Work stress

UR - https://www.scopus.com/pages/publications/15944363087

U2 - 10.1016/j.biopsycho.2004.07.004

DO - 10.1016/j.biopsycho.2004.07.004

M3 - Article

C2 - 15804544

SN - 0301-0511

VL - 69

SP - 167

EP - 179

JO - Biological Psychology

JF - Biological Psychology

IS - 2

ER -

Heightened cortisol responses to daily stress in working women at familial risk for breast cancer

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