Hydrogen-bonding controlled rigidity of an isoindoline-derived nitroxide spin label for nucleic acids

Dnyaneshwar B. Gophane; Snorri Th Sigurdsson

doi:10.1039/c2cc36389e

Hydrogen-bonding controlled rigidity of an isoindoline-derived nitroxide spin label for nucleic acids

Dnyaneshwar B. Gophane
, Snorri Th Sigurdsson

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Rannsóknarafurð: Framlag til fræðitímarits › Grein › ritrýni

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Nucleosides spin-labelled with isoindoline-derived benzimidazole (^ImU) and benzoxazole (^OxU) moieties were synthesized and incorporated into DNA oligonucleotides. Both labels display limited mobility in duplex DNA but ^ImU was less mobile, which was attributed to an intramolecular hydrogen bond between the N-H of the imidazole and O4 of the uracil nucleobase.

Upprunalegt tungumál	Enska
Síður (frá-til)	999-1001
Síðufjöldi	3
Fræðitímarit	Chemical Communications
Bindi	49
Númer tölublaðs	10
DOI	https://doi.org/10.1039/c2cc36389e
Útgáfustaða	Útgefið - 3 jan. 2013

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10.1039/c2cc36389e

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title = "Hydrogen-bonding controlled rigidity of an isoindoline-derived nitroxide spin label for nucleic acids",

abstract = "Nucleosides spin-labelled with isoindoline-derived benzimidazole (ImU) and benzoxazole (OxU) moieties were synthesized and incorporated into DNA oligonucleotides. Both labels display limited mobility in duplex DNA but ImU was less mobile, which was attributed to an intramolecular hydrogen bond between the N-H of the imidazole and O4 of the uracil nucleobase.",

author = "Gophane, \{Dnyaneshwar B.\} and Sigurdsson, \{Snorri Th\}",

year = "2013",

month = jan,

day = "3",

doi = "10.1039/c2cc36389e",

language = "English",

volume = "49",

pages = "999--1001",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Hydrogen-bonding controlled rigidity of an isoindoline-derived nitroxide spin label for nucleic acids

AU - Gophane, Dnyaneshwar B.

AU - Sigurdsson, Snorri Th

PY - 2013/1/3

Y1 - 2013/1/3

N2 - Nucleosides spin-labelled with isoindoline-derived benzimidazole (ImU) and benzoxazole (OxU) moieties were synthesized and incorporated into DNA oligonucleotides. Both labels display limited mobility in duplex DNA but ImU was less mobile, which was attributed to an intramolecular hydrogen bond between the N-H of the imidazole and O4 of the uracil nucleobase.

AB - Nucleosides spin-labelled with isoindoline-derived benzimidazole (ImU) and benzoxazole (OxU) moieties were synthesized and incorporated into DNA oligonucleotides. Both labels display limited mobility in duplex DNA but ImU was less mobile, which was attributed to an intramolecular hydrogen bond between the N-H of the imidazole and O4 of the uracil nucleobase.

UR - https://www.scopus.com/pages/publications/84872065455

U2 - 10.1039/c2cc36389e

DO - 10.1039/c2cc36389e

M3 - Article

C2 - 23250475

SN - 1359-7345

VL - 49

SP - 999

EP - 1001

JO - Chemical Communications

JF - Chemical Communications

IS - 10

ER -

Hydrogen-bonding controlled rigidity of an isoindoline-derived nitroxide spin label for nucleic acids

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