Myelin lesions in the rabbit eye model as a bystander effect of herpes simplex and visna virus sensitization

Krister Kristensson; Halldor Thormar; Henryk M. Wisniewski

doi:10.1007/BF00690522

Myelin lesions in the rabbit eye model as a bystander effect of herpes simplex and visna virus sensitization

Krister Kristensson
, Halldor Thormar
, Henryk M. Wisniewski

Líf- og umhverfisvísindadeild

Háskóli Íslands

Rannsóknarafurð: Framlag til fræðitímarits › Grein › ritrýni

Útdráttur

Rabbits were immunized with herpes simplex and visna virus in complete Freund's adjuvant. Uv-inactivated herpes virus and the purified visna virus protein p 25 injected intraocularly into these rabbits elicited a moderate inflammatory cell infiltration in the epiretinal myelinated nerve fiber bundles accompanied by signs of demyelination. It is therefore apparent that also viral antigen can induce myelin lesions as a socalled "bystander effect" of a cell-mediated immune response (bystander demyelination).

Upprunalegt tungumál	Enska
Síður (frá-til)	215-217
Síðufjöldi	3
Fræðitímarit	Acta Neuropathologica
Bindi	48
Númer tölublaðs	3
DOI	https://doi.org/10.1007/BF00690522
Útgáfustaða	Útgefið - jan. 1979

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10.1007/BF00690522

Vitna í þetta

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title = "Myelin lesions in the rabbit eye model as a bystander effect of herpes simplex and visna virus sensitization",

abstract = "Rabbits were immunized with herpes simplex and visna virus in complete Freund's adjuvant. Uv-inactivated herpes virus and the purified visna virus protein p 25 injected intraocularly into these rabbits elicited a moderate inflammatory cell infiltration in the epiretinal myelinated nerve fiber bundles accompanied by signs of demyelination. It is therefore apparent that also viral antigen can induce myelin lesions as a socalled {"}bystander effect{"} of a cell-mediated immune response (bystander demyelination).",

keywords = "Demyelination, Herpes simplex virus, Visna virus",

author = "Krister Kristensson and Halldor Thormar and Wisniewski, \{Henryk M.\}",

year = "1979",

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T1 - Myelin lesions in the rabbit eye model as a bystander effect of herpes simplex and visna virus sensitization

AU - Kristensson, Krister

AU - Thormar, Halldor

AU - Wisniewski, Henryk M.

PY - 1979/1

Y1 - 1979/1

N2 - Rabbits were immunized with herpes simplex and visna virus in complete Freund's adjuvant. Uv-inactivated herpes virus and the purified visna virus protein p 25 injected intraocularly into these rabbits elicited a moderate inflammatory cell infiltration in the epiretinal myelinated nerve fiber bundles accompanied by signs of demyelination. It is therefore apparent that also viral antigen can induce myelin lesions as a socalled "bystander effect" of a cell-mediated immune response (bystander demyelination).

AB - Rabbits were immunized with herpes simplex and visna virus in complete Freund's adjuvant. Uv-inactivated herpes virus and the purified visna virus protein p 25 injected intraocularly into these rabbits elicited a moderate inflammatory cell infiltration in the epiretinal myelinated nerve fiber bundles accompanied by signs of demyelination. It is therefore apparent that also viral antigen can induce myelin lesions as a socalled "bystander effect" of a cell-mediated immune response (bystander demyelination).

KW - Demyelination

KW - Herpes simplex virus

KW - Visna virus

UR - https://www.scopus.com/pages/publications/0018571319

U2 - 10.1007/BF00690522

DO - 10.1007/BF00690522

M3 - Article

C2 - 230691

SN - 0001-6322

VL - 48

SP - 215

EP - 217

JO - Acta Neuropathologica

JF - Acta Neuropathologica

IS - 3

ER -

Myelin lesions in the rabbit eye model as a bystander effect of herpes simplex and visna virus sensitization

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