TY - JOUR
T1 - White matter hyperintensity shape is associated with long-term dementia risk
AU - Keller, Jasmin Annica
AU - Sigurdsson, Sigurdur
AU - Klaassen, Kelly
AU - Hirschler, Lydiane
AU - van Buchem, Mark A.
AU - Launer, Lenore J.
AU - van Osch, Matthias J.P.
AU - Gudnason, Vilmundur
AU - de Bresser, Jeroen H.J.M.
N1 - Funding Information: The authors want to thank Myriam Jaarsma‐Coes for her help with the software. The Age, Gene/Environment Susceptibility‐Reykjavik Study was supported by NIH contracts N01‐AG‐1‐2100 and HHSN27120120022C, the NIA Intramural Research Program, Hjartavernd (Icelandic Heart Association), and Althingi (Icelandic Parliament). This work was supported by an Alzheimer's Nederland grant (WE.03‐2019‐08) to Jeroen de Bresser. Publisher Copyright: © 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
PY - 2023/12
Y1 - 2023/12
N2 - INTRODUCTION: We aimed to investigate the association between white matter hyperintensity (WMH) shape and volume and the long-term dementia risk in community-dwelling older adults.METHODS: Three thousand seventy-seven participants (mean age: 75.6 ± 5.2 years) of the Age Gene/Environment Susceptibility (AGES)-Reykjavik study underwent baseline 1.5T brain magnetic resonance imaging and were followed up for dementia (mean follow-up: 9.9 ± 2.6 years).RESULTS: More irregular shape of periventricular/confluent WMH (lower solidity (hazard ratio (95% confidence interval) 1.34 (1.17 to 1.52), p < .001) and convexity 1.38 (1.28 to 1.49), p < .001); higher concavity index 1.43 (1.32 to 1.54), p < .001) and fractal dimension 1.45 (1.32 to 1.58), p < .001)), higher total WMH volume (1.68 (1.54 to 1.87), p < .001), higher periventricular/confluent WMH volume (1.71 (1.55 to 1.89), p < .001), and higher deep WMH volume (1.17 (1.08 to 1.27), p < .001) were associated with an increased long-term dementia risk.DISCUSSION: WMH shape markers may in the future be useful in determining patient prognosis and may aid in patient selection for future preventive treatments in community-dwelling older adults.
AB - INTRODUCTION: We aimed to investigate the association between white matter hyperintensity (WMH) shape and volume and the long-term dementia risk in community-dwelling older adults.METHODS: Three thousand seventy-seven participants (mean age: 75.6 ± 5.2 years) of the Age Gene/Environment Susceptibility (AGES)-Reykjavik study underwent baseline 1.5T brain magnetic resonance imaging and were followed up for dementia (mean follow-up: 9.9 ± 2.6 years).RESULTS: More irregular shape of periventricular/confluent WMH (lower solidity (hazard ratio (95% confidence interval) 1.34 (1.17 to 1.52), p < .001) and convexity 1.38 (1.28 to 1.49), p < .001); higher concavity index 1.43 (1.32 to 1.54), p < .001) and fractal dimension 1.45 (1.32 to 1.58), p < .001)), higher total WMH volume (1.68 (1.54 to 1.87), p < .001), higher periventricular/confluent WMH volume (1.71 (1.55 to 1.89), p < .001), and higher deep WMH volume (1.17 (1.08 to 1.27), p < .001) were associated with an increased long-term dementia risk.DISCUSSION: WMH shape markers may in the future be useful in determining patient prognosis and may aid in patient selection for future preventive treatments in community-dwelling older adults.
KW - cerebral small vessel disease
KW - cognitive decline
KW - dementia
KW - magnetic resonance imaging
KW - white matter hyperintensities
UR - https://www.scopus.com/pages/publications/85161668561
U2 - 10.1002/alz.13345
DO - 10.1002/alz.13345
M3 - Article
C2 - 37303267
SN - 1552-5260
VL - 19
SP - 5632
EP - 5641
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 12
ER -